Main Logo
Logo

Society for Pediatric Radiology – Poster Archive

  187
  0
  0
 
 


Final ID: Paper #: 011

Ferumoxytol-enhanced 4D Flow MRI: Comparison of Image Quality with Extracellular Gadolinium-based Contrast and Non-contrast Studies in Children with Congenital Heart Disease

Purpose or Case Report: Three dimensional magnetic resonance angiography (3DMRA) and two-dimensional phase contrast are commonly used for assessment of anatomy and flow in congenital heart disease. Time-resolved, three-dimensional phase contrast MRI (4D flow) provides complete volumetric coverage of the chest with flow assessment in any plane. How the addition of ferumoxytol (Fe), a blood pool contrast, changes 4D flow magnitude image quality relative to extracellular gadolinium-based contrast agents (GB) and non-contrast (NC) exams is unknown. We compare image quality measurements in Fe, GB and NC 4D flow with ECG-gated, respiratory-navigated 3DMRA.
Methods & Materials: 32 patients with Fe 4D flow were age-matched to 33 patients with GB and 13 patients with NC 4D flow. 4D flow image quality was assessed by (1) aortic signal-to-noise ratio (SNR) (2) aortic contrast-to-noise ratio (CNR) (3) qualitative rating by 2 blinded readers. Ascending aorta (Ao), branch pulmonary arteries (PA), right superior vena cava (RSVC), pulmonary veins (PV), endocardial border (EB), and coronary artery origins (CAO) were rated 0=Not included 1=Nondiagnostic 2=Diagnostic. Ascending and descending aorta dimensions (AD, DD) on 4D flow magnitude images were compared to 3DMRA. Agreement between readers was assessed by taking the difference between raters’ scores and performing Wilcoxon rank sum test.
Results: Aortic SNR and CNR was significantly higher in Fe 4D flow (SNR: FE 56±26, GB 35±13, NC 24±12; CNR: FE 19±14, GB -7±15, NC -15±12, p<.001). AD and DD correlated well with 3DMRA for Fe and GBCA but not NC (AD R2: FE .98, GB .94, NC .54; DD R2: FE .96, GB .95, NC .6). All structures were rated diagnostic more often for Fe than GBCA and NC (p<.001). Ao was rated diagnostic on 32(100%) FE, 12(36%) GB, and 3(23%) NC. EB and PV were seen on most Fe studies (63% and 81% respectively); non-diagnostic on all NC and all but 1 GB showing PV. CAO were rarely diagnostic (FE 5(16%), GB 1(3%), no NC). For structures most often seen (Ao, PA, right SVC), interrater agreement was higher in Fe than GB and NC (p<.05).
Conclusions: MRA image quality varies between contrast types. NC 4D flow magnitude images are nondiagnostic for measurements. Qualitatively, Fe image quality is superior to GB and NC, including for detection of the endocardial border and small structures such as pulmonary veins. If 4D flow is to replace 2D-PC and 3D MRA as a single acquisition for vascular and flow assessment, Fe is essential to creating diagnostic magnitude images.
  • Griffin, Lindsay  ( Ann and Robert Lurie Children's Hospital , Chicago , Illinois , United States )
  • Gupta, Aditi  ( Ann and Robert Lurie Children's Hospital , Chicago , Illinois , United States )
  • Berhane, Haben  ( Ann and Robert Lurie Children's Hospital , Chicago , Illinois , United States )
  • Husain, Nazia  ( Ann and Robert Lurie Children's Hospital , Chicago , Illinois , United States )
  • Rigsby, Cynthia  ( Ann and Robert Lurie Children's Hospital , Chicago , Illinois , United States )
Session Info:

Scientific Session I-B: Cardiovascular

Cardiovascular

SPR Scientific Papers

More abstracts on this topic:
Patent Ductus Arteriosus (PDA) – Variations and their Importance in Managing Patients with Congenital Heart Disease

Gilligan Leah, Popescu Andrada, Griffin Lindsay, Rigsby Cynthia, Bardo Dianna

Fetal Cardiac Magnetic Resonance Imaging (CMR) (FCMR) Correlation with Prenatal (echo) and Postnatal Imaging

Bardo Dianna, Lindblade Christopher, Wishah Fidaa, Patel Mittun, Cornejo Patricia, Ellsworth Erik, Awerbach Jordan, Goncalves Luis

More abstracts from these authors:
Due to circumstances surrounding the coronavirus pandemic, this final ePoster exhibit was not submitted.
You have to be authorized to contact abstract author. Please, Login or Signup.

Please note that this is a separate login, not connected with your credentials used for the SPR main website.

Not Available

Comments

We encourage you to join the discussion by posting your comments and questions below.

Presenters will be notified of your post so that they can respond as appropriate.

This discussion platform is provided to foster engagement, and stimulate conversation and knowledge sharing.

Please click here to review the full terms and conditions for engaging in the discussion, including refraining from product promotion and non-constructive feedback.

 

You have to be authorized to post a comment. Please, Login or Signup.

Please note that this is a separate login, not connected with your credentials used for the SPR main website.


   Rate this abstract  (Maximum characters: 500)