Main Logo
Logo

Society for Pediatric Radiology – Poster Archive

  181
  0
  0
 
 


Final ID: Poster #: EDU-018 (S)

Normal and Abnormal Mielinization Patterns

Purpose or Case Report: Myelination it's a dynamic process through which a lipoprotein sheath that covers the axons develops. It begins at the 4th month of gestation and reaches its maximum at 24 months and occurs from caudal to rostral, from dorsal to ventral, from central to peripheral

Normal myelination by MRI

Sequences
T1 key sequence to evaluate myelination <1 year. The signal reflects the presence of proteins
T2 key sequence to evaluate myelination 1 and 2 years As the myelin sheaths thicken the surrounding interstitial water moves
FLAIR, DP, DTI complementary sequences

T1WI
RN Brain stem, optical tracts, anterior commissure, ventral thalamus, posterior limb of the internal capsule, rolandic and perirolandic gyrus
2 months deep white matter and anterior limb of internal capsule
4 months Splenium, optical radiations become more evident, cerebellar white matter
6 months Genu, body and splenus of the corpus callosum
8 months U fibers in occipital lobes progressing slowly to frontal and temporal at one year of age.
10-12 months Appearance of myelination with adult pattern in T1WI

T2WI
RN
Dorsal brain stem, posterior limb of the internal capsule, ventral thalamus, perirolandic gyrus
2 months Posterior internal capsule arm, semiovale centrum and optical tracts
4 months Optical radiation and subcortical white matter
6 months Splenium
8 months Genu, body and splenic corpus callosum, anterior arm of the internal capsule
12 months cerebellar white matter and occipital subcortical U fibers
18 months Frontal white matter. Some residual hyperintense signals around the trigons of the lateral ventricles
36 months Myelination appearance with adult pattern in T2WI

Myelination Terminal Zones
Normal variant of development
Zones of incomplete myelination
Hyperintense, bilateral and symmetric foci in dorsolateral WM to the atrium of the lateral ventricle

Abnormal Patterns
Delayed myelination Situations in which myelination is slow but present.Usually bilateral and symmetric

Hypermyelination Rare pathology, it can be local or generalized. Sturge Webber, epilepsy and late sequelae of perinatal hypoxia.

Hypomyelinization Permanent deficit of the myelin deposit. Unlike the delay of myelination these do not present myelination over time
It can be seen as normal myelination in T1 but with deficit in T2

White matter diseases
Demyelinating diseases They are acquired and have destruction of normal myelin
Demyelinating diseases Hereditary enzyme deficiency that causes abnormal myelin formation, destruction or turnover
Methods & Materials:
Results:
Conclusions:
Session Info:

Posters - Educational (SLARP)

Neuroradiology

SPR Posters - Educational

More abstracts on this topic:
More abstracts from these authors:
Vascular Anomalies: Diagnostic Approach and Endovascular Treatment

Guillen Gutierrez Cinthia, Rodriguez Garza Claudia, De Luna Vega Raul, Hernández Grimaldo Edgar, Elizondo Riojas Guillermo

Pulmonary Manifestations of Cystic Fibrosiss: Jump into Bhalla Score and Brasfield Score Systems

Guillen Gutierrez Cinthia, Rodriguez Garza Claudia, Elizondo Riojas Guillermo, Hernández Grimaldo Edgar, Garza Acosta Andrea

Preview
Poster____EDU-018_(S).pdf
You have to be authorized to contact abstract author. Please, Login or Signup.

Please note that this is a separate login, not connected with your credentials used for the SPR main website.

Not Available

Comments

We encourage you to join the discussion by posting your comments and questions below.

Presenters will be notified of your post so that they can respond as appropriate.

This discussion platform is provided to foster engagement, and stimulate conversation and knowledge sharing.

Please click here to review the full terms and conditions for engaging in the discussion, including refraining from product promotion and non-constructive feedback.

 

You have to be authorized to post a comment. Please, Login or Signup.

Please note that this is a separate login, not connected with your credentials used for the SPR main website.


   Rate this abstract  (Maximum characters: 500)