Purpose or Case Report: Coccidioidomycosis is an endemic fungus in the American southwest, and all age groups are susceptible to this infection. While acute and chronic pneumonia is the most common manifestation, disseminated infections particularly in immunocompromised patients can involve the skin, skeletal system and central nervous system. Five cases with different clinical manifestations of coccidioidomycosis in the pediatric population from our institution will be presented to illustrate the spectrum of this infection. The case series will explore the various imaging patterns, including pulmonary consolidation and miliary nodules, axial and appendicular osteomyelitis, and leptomeningeal and intraocular disease. While no single imaging feature is specific to this pathogen, the possibility of Coccidioidomycosis should be raised given certain clinical presentations and imaging findings in order to reach a timely diagnosis and begin treatment with anti-fungal therapy.
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