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Society for Pediatric Radiology – Poster Archive


Final ID: Poster #: EDU-012 (T)

Importance of medical imaging and radiographic findings in skeletal manifestations of Langerhans Cell Histiocytosis

Purpose or Case Report: Langerhans Cell Histiocytosis (LCH), is a disorder that primarily affects children, but can affect individuals of all ages. Langerhans cells are cells that are responsible for regulating immune system in our bodies. They are mostly found in the skin, spleen, lymph nodes, liver and bone marrow. In patients who have LCH, these cells grow and multiply excessively. The abnormal growth of the Langerhans cells causes a formation of tumors called granulomas. LCH can affect different areas of the body: skin, nails, lymph nodes, gastrointestinal tract, central nervous system, pituitary and thyroid gland, liver, lungs and bones. The severity and symptoms of the disease vary in individual patients and are dependent on the organs and systems affected. Oftentimes, LCH can be found in multiple areas of the body and when that happens, the disease becomes a multisystem disease. The most common system affected by LCH, seen in about 80 % of individuals affected, is the skeletal system. Granulomas, which develop most commonly in the flat bones such as skull and long bones of arms and legs, cause sclerotic and lytic lesions that can in turn become the cause of pathologic fractures. Therefore it is crucial, to recognize the radiographic signs of skeletal manifestations of LCH. Radiography is the preliminary imaging of choice and skeletal surveys are oftentimes the best assessment of the status of LCH prior and post treatment. The purpose of this abstract is to describe radiographic appearances associated with Langerhans Cell Histiocytosis. In order to confirm the importance of follow up skeletal surveys, I will present cases and associated radiographs that show signs of LCH prior to treatment and post treatment.
Methods & Materials:
  • Ulikowska, Ewelina  ( Ann and Robert Lurie Childresn Hospital , Des Plaines , Illinois , United States )
Session Info:

Technologist Posters - Educational


Technologist Posters - Educational

More abstracts on this topic:
Does a skeletal survey detect additional bone lesions of Langerhans Cell Histiocytosis in children undergoing 18F-FDG Positron Emission Tomography-Computed Tomography?

Aboagye Rosemond, Bajno Lydia, Nadel Helen, Potts James, Bray Heather

Comparing diffusion-weighted MRI and 18F-FDG PET/MRI for staging and restaging of Langerhans Cell Histiocytosis

Nyalakonda Ramyashree, Muehe Anne, Iles Benjamin, Theruvath Ashok, Siedek Florian, Agarwal Vibhu, Hawk Kristina, Jeng Michael, Daldrup-link Heike

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