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Final ID: Paper #: 106

Magnetic Resonance Angiography and T2* Mapping of Placenta

Purpose or Case Report: Both placental vascular density and oxygenation can indicate placenta health. MRA is a powerful tool to evaluate tissue vasculature but with limited applications because of the use of contrast agents. T2* maps can be used to estimate the placental oxygen reserve. In this work, we acquired non-contrast enhanced MRA and T2* maps to evaluate placental vasculature and oxygenation.
Methods & Materials: Two pregnant women were recruited for this study. One woman (Subject A, GA: 28+2/7w, fetal hydrocephalus) was studied on a 1.5T Siemens Aera system with an 8-channel body coil, and the other one (Subject B, GA: 36+2/7w, normal) was studied on a 3T Siemens Verio system with a 6-channel flex coil and a 4-channel spine coil. A 2D time-of-flight sequence and 2D multi-echo GRE sequence were run for each subject to generate the MRA and T2* maps. The sequence parameters were: at 1.5T:1)MRA: TR/TE=23/5.6ms, in-plane resolution=0.56×0.56mm2, slice thickness=3mm, BW=245Hz/px, and flip angle=50deg; and 2)T2*mapping: TR/TE/detTE=93/5/5ms, echo number=12, in-plane resolution=1.13×2.25mm2, slice thickness=3mm, BW=230Hz/px, and flip angle=20deg; while at 3T:1) MRA: TR/TE=22/4.92ms, in-plane resolution =0.66×0.82mm2, slice thickness=2mm, BW=241Hz/px, and flip angle=50deg; and 2)T2*mapping: TR/TE/detTE=70/4/4ms , echo number=12, in-plane resolution =2.97×2.97mm2, slice thickness=4mm, BW=501Hz/px, and flip angle=30deg.
Results: The placenta appeared inhomogeneous in the T2*-weighted image. Since placenta cotyledons are brighter in T2 HASTE image, these brighter regions in both T2* weighted images and T2* maps were taken to correspond to the cotyledons in this data as well. For each subject, we identified one cotyledon as the target cotyledon from 20 slices of T2* map. The T2* value of the placenta measured from one slice was 100.6±39.2ms for Subject A and 32.2±14.2ms for Subject B. The MRA of the entire placenta were well displayed. For both subjects, it is easy to identify the umbilical vessels, chorionic vessels and stem vessels. The umbilical vein can be distinguished from umbilical arteries for Subject A. Chorionic vessels and stem vessels can be identified for both subjects in the target cotyledons. Interestingly, in Subject A, it is possible to see some stem vessels branching off the chorionic vessels.
Conclusions: Both MRA and T2* maps can provide key information for the evaluation of placental vasculature and oxygenation and could provide a tool to investigate abnormal pregnancy and predict fetal outcome.
  • Qu, Feifei  ( Department of Radiology, School of Medicine, Wayne State University , Detroit , Michigan , United States )
  • Qian, Zhaoxia  ( Department of Radiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai , China )
  • Yadav, Brijesh  ( Department of Radiology, School of Medicine, Wayne State University , Detroit , Michigan , United States )
  • Romero, Roberto  ( Perinatology Research Branch, NICHD/NIH/DHHS, Hutzel Women’s Hospital , Detroit , Michigan , United States )
  • Haacke, E.  ( Department of Radiology, School of Medicine, Wayne State University , Detroit , Michigan , United States )
  • Sun, Taotao  ( Department of Radiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai , China )
  • Patwardhan, Sanjay  ( Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, Wayne State University , Detroit , Michigan , United States )
  • Patwardhan, Manasi  ( Department of Obstetrics and Gynecology, Maternal-Fetal Medicine, Wayne State University , Detroit , Michigan , United States )
  • Jaiman, Sunil  ( Department of Pathology, School of Medicine, Wayne State University , Detroit , Michigan , United States )
  • Jellal, Pavan  ( Department of Radiology, School of Medicine, Wayne State University , Detroit , Michigan , United States )
  • Mody, Swati  ( Department of Radiology, Children Hospital of Michigan , Detroit , Michigan , United States )
  • Marin Concha, Julio  ( Perinatology Research Branch, NICHD/NIH/DHHS, Hutzel Women’s Hospital , Detroit , Michigan , United States )
  • Jiang, Ling  ( Department of Radiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai , China )
Session Info:

Scientific Session IV-B: Fetal/Neonatal

Fetal Imaging / Neonatal

SPR Scientific Papers

More abstracts on this topic:
A Practical Guide to MRI Evaluation of the Placenta

Brown Brandon, Shea Lindsey, Marine Megan

Fetal Liver T2* Values using 3.0 T MRI

Marin Concha Julio, Qu Feifei, Hernandez Andrade Edgar, Jella Pavan, Mody Swati, Subramanian Karthikeyan, Ghassaban Kiarash, Romero Roberto, Haacke E.

More abstracts from these authors:
Comparison between Ultrasound and MRI measurements of fetal intracranial volume

Neelavalli Jaladhar, Romero Roberto, Hernandez-andrade Edgar, Mody Swati, Yadav Brijesh, Kabrera Maria, Jella Pavan, Yeo Lami, Haacke Ewart, Hassan Sonia

Fetal Liver T2* Values using 3.0 T MRI

Marin Concha Julio, Qu Feifei, Hernandez Andrade Edgar, Jella Pavan, Mody Swati, Subramanian Karthikeyan, Ghassaban Kiarash, Romero Roberto, Haacke E.

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