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Final ID: Poster #: SCI-006

Fetal Liver T2* Values using 3.0 T MRI

Purpose or Case Report: Magnetic Resonance Imaging is a powerful tool for the detection of ferromagnetic components. This property can be used for the early detection of pathologic conditions related to liver iron overload. Neonatal hemochromatosis and hemosiderosis are conditions associated with severe liver disease. Infections like parvovirus and cytomegalovirus, metabolic conditions and gestational allo-immune liver disease can produce neonatal hemochromatosis phenotype.
Fetal iron overload can be detected early by using T2* multi-echo gradient sequence.
There are only few studies reporting standard T2* values of the fetal liver at 1.5 T.
The aim of this study is to evaluated the standard T2* values of the fetal liver using prenatal MRI with 3.0 T.
Methods & Materials: The T2* sequence of the liver was obtained from eight fetuses (5 normal, 2 IUGR and one placenta hematoma) between 24 and 30 gestational weeks at 3.0 T Siemens Vero MRI system with a 6-channel flex coil and a 4-channel spine coil. T2* weighted images were collected by multi-echo Spoiled Gradient Echo sequences with all the echoes flow compensated. The data were collected by four difference protocols. T2 Half-Fourier Acquisition Single-shot Turbo Spin Echo (T2-HASTE) sequence was also performed as the reference. All the data analyses were performed by custom-written software in MATLABTM. T2* map was created by a pixel wise exponential fitting, and only the voxels with a goodness of fit higher than 0.85 were considered as reliable results which were used in the calculation of average and standard deviation of T2* value of the liver.
Results: Eight Singleton pregnant women underwent fetal MRI for research purposes in a 3.0 Tesla magnet. The average gestational age was 28.5 ± 3.8 weeks (range between 24 – 30 weeks).
The mean fetal liver T2* value for the normal subjects were 15.8 ± 2.1 ms. The lowest value was 12.1 ms in a subject with 30 + 3/7 weeks of gestation, and the higher value was 21.6 ms in a subject with 30 + 5/7 weeks of gestation. No significant variation of T2* values crossing gestational ages was found. The liver T2* value in the case of placental hematoma at 25 weeks was 21.5 ms. The values for the IUGR subjects were 10 ms for the one at 35 weeks and 16.1 ms for the other one at 24 + 2/7 weeks.
Conclusions: Noninvasive evaluation of the fetal liver iron deposition is possible with T2* MRI sequences using 3.0 Tesla. This study is important as a quantitative standard reference value especially in the assessment of chronic fetal liver conditions.
  • Marin Concha, Julio  ( Perinatology Research Branch , NICHD/NIH/DHHS, Bethesda, Maryland, and Detroit, Michigan, USA , Detroit , Michigan , United States )
  • Qu, Feifei  ( Department of Radiology, Wayne State University School of Medicine , Detroit , Michigan , United States )
  • Hernandez Andrade, Edgar  ( Perinatology Research Branch , NICHD/NIH/DHHS, Bethesda, Maryland, and Detroit, Michigan, USA , Detroit , Michigan , United States )
  • Jella, Pavan  ( Department of Radiology, Wayne State University School of Medicine , Detroit , Michigan , United States )
  • Mody, Swati  ( Department of Radiology, Children's Hospital of Michigan , Detroit , Michigan , United States )
  • Subramanian, Karthikeyan  ( Department of Radiology, Wayne State University School of Medicine , Detroit , Michigan , United States )
  • Ghassaban, Kiarash  ( Department of Radiology, Wayne State University School of Medicine , Detroit , Michigan , United States )
  • Romero, Roberto  ( Perinatology Research Branch , NICHD/NIH/DHHS, Bethesda, Maryland, and Detroit, Michigan, USA , Detroit , Michigan , United States )
  • Haacke, E.  ( Department of Radiology, Wayne State University School of Medicine , Detroit , Michigan , United States )
Session Info:

Posters - Scientific

Fetal Imaging / Neonatal

SPR Posters - Scientific

More abstracts on this topic:
More abstracts from these authors:
Magnetic Resonance Angiography and T2* Mapping of Placenta

Qu Feifei, Qian Zhaoxia, Yadav Brijesh, Romero Roberto, Haacke E., Sun Taotao, Patwardhan Sanjay, Patwardhan Manasi, Jaiman Sunil, Jellal Pavan, Mody Swati, Marin Concha Julio, Jiang Ling

Comparison between Ultrasound and MRI measurements of fetal intracranial volume

Neelavalli Jaladhar, Romero Roberto, Hernandez-andrade Edgar, Mody Swati, Yadav Brijesh, Kabrera Maria, Jella Pavan, Yeo Lami, Haacke Ewart, Hassan Sonia

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