Purpose or Case Report: Retinoblastoma is an aggressive malignant tumor and the most common malignant intraocular tumor in children. The key to better treatment is early detection, before it metastasizes. We aim to provide better quantifiable measurements to assist the clinician in the evaluation of tumor response.
Currently, 2D sonography is performed to confirm the diagnosis, and after each sequential treatment. Thus, a change in tumor size during treatment is made by 2D evaluation only. Three-dimensional (3D) ultrasonography is an enhancement of the ultrasonographic technique that allows an examiner to obtain, non-invasively, 3D volumetric images. 3D ultrasound imaging is primarily performed in the Ob/Gyn setting. However, more and more it is being used for other areas of the body. We think that 3D technology may be particularly useful since retinoblastomas can have very irregular shapes and, therefore, simpler techniques to estimate volumes such as the performance of three orthogonal two-dimensional measurements multiplied by 0.523 to estimate the volume of an oval structure using the ellipsoid formula may be unreliable. We present several case studies performed at our institution with a developed protocol for such imaging along with the results of the study.
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