Purpose or Case Report: Pediatric adrenal masses are rare but significant findings in clinical radiology, requiring careful evaluation due to their varied etiologies ranging from benign lesions to malignant tumors. For radiology residents, fellows, and attending radiologists, a systematic approach is essential for accurate diagnosis and management. This review highlights key imaging pearls and common pitfalls associated with pediatric adrenal lesions. The "pearls" include recognizing age-specific differentials, the importance of correlating clinical and biochemical findings, and the utility of advanced imaging techniques such as MRI for tissue characterization. Neuroblastoma, the most common malignant pediatric adrenal tumor, should be distinguished from benign entities like adrenal hemorrhage or hyperplasia based on imaging characteristics such as calcification, organ displacement, and vascular encasement. In contrast, pitfalls often arise from misinterpreting normal anatomic variations or failing to account for the dynamic nature of some lesions, such as hemorrhage or pheochromocytoma, which may change in size or appearance over time. Furthermore, the overlap in imaging features between benign and malignant lesions can lead to diagnostic uncertainty. This review emphasizes the need for a multidisciplinary approach, incorporating clinical, laboratory, and imaging data to avoid misdiagnosis and unnecessary interventions. Understanding the pearls and pitfalls of pediatric adrenal mass imaging will aid radiologists in providing more accurate and timely diagnoses, ultimately improving patient outcomes.
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