Hopkins Erin,  James Anna,  Hayward Mark

Final Pr. ID: Poster #: CR-045

A 14-year-old male from a rural community presented with a 4-week history of loose stools and recent lower respiratory tract infection. Initial investigations revealed elevated inflammatory and liver markers (CRP 100 mg/L, ALT 90 U/L, ALP 586 U/L), thrombocytosis (661 × 10^9/L), anemia (Hgb 74 g/L), and hypoalbuminemia (21 g/L). Ultrasound demonstrated a “starry sky” liver and gallbladder sludge. CT of the chest, abdomen, and pelvis showed multiple bilateral pulmonary nodules, small pleural effusions, mild colitis, and enlarged mesenteric and periportal lymph nodes, initially raising concern for metastatic disease. PET/CT revealed FDG-avid pulmonary nodules and lymph nodes near the pancreatic head and tail. MRI/MRCP confirmed nodal conglomerates in these regions without a discrete pancreatic lesion. Testicular ultrasound was normal. There were no superficial FDG-avid lymph nodes available for biopsy. Laparoscopic resection of the pancreatic tail lymph node conglomerate was considered but not pursued as the patient began to improve clinically and biochemically. Infectious and autoimmune workup was largely negative except for a low-titre positive ANA (polar/Golgi-like pattern, 1:80). IgG subclass testing showed isolated IgG1 elevation (IgG4 negative). No specific infectious or malignant etiology was identified. The patient’s condition improved spontaneously within three weeks, with normalization of inflammatory and liver parameters and interval reduction of lymphadenopathy on follow-up imaging. This case highlights a self-limiting multisystem inflammatory process that radiologically mimicked disseminated malignancy. Knowledge of transient self-limiting autoinflammatory syndromes should be considered to prevent unnecessary invasive investigations or treatments. Read More

Authors:  Hopkins Erin , James Anna , Hayward Mark

Keywords:  Autoinflammation, FDG PET, Lymphadenopathy

Alsharief Alaa,  Laxer Ronald,  Stimec Jennifer,  Babyn Paul,  Man Carina,  Doria Andrea

Final Pr. ID: Poster #: EDU-069

1. To review the contemporary literature and present an updated list of musculoskeletal and non-musculoskeletal imaging findings of patients with autoinflammatory diseases in our hospital. Most of these patients are found to have a genetic mutation that is responsible for their disease.

2. To present follow-up imaging findings, when available, and correlate those with patients’ symptoms and type of treatment administered in approximately 40 patients with autoinflammatory diseases such as Cryopyrin-associated autoinflammatory syndrome, familial Mediterranean fever, PAPA (pyogenic arthritis, pyoderma gangrenousum, and acne) syndrome and much more. These findings can be related to disease progression, treatment response or treatment-induced changes. Read More

Authors:  Alsharief Alaa , Laxer Ronald , Stimec Jennifer , Babyn Paul , Man Carina , Doria Andrea

Keywords:  Autoinflammation, fever, Rheumatology

Molto Garcia Jose Francisco,  Nair Lakshmi,  Kahn Ilana

Final Pr. ID: Poster #: EDU-104

MOGAD varies widely in MRI patterns and has overlapping imaging features with other conditions such as leukodystrophies, infections or other autoimmune diseases. The 2023 MOGAD diagnostic criteria highlights the diagnostic role of MR imaging to diagnose patients that have low positive myelin oligodendrocyte glycoprotein IgG titers or when the titers are not available. This poster aims to review the various MR imaging appearances of Pediatric MOGAD. We will review the most common phenotypes such as ADEM, optic neuritis or longitudinally extensive myelitis but also others not as common, such as brainstem and cerebellar involvement, leukodystrophy-like or cranial and peripheral neuropathy patterns. We will also provide teaching points and some clues for the differential diagnosis, including the discussion of a pathologic slide of a tumefactive case that led to biopsy. Finally, this poster will highlight the importance of ASL to diagnose cortical forms of MOGAD, which may be subtle on conventional sequences but very apparent on perfusion imaging. We certainly believe that this poster may be of great help to familiarize radiologists working in institutions where MOGAD is not commonly encountered. Read More

Authors:  Molto Garcia Jose Francisco , Nair Lakshmi , Kahn Ilana

Keywords:  MR, Autoinflammation, Pediatric Neuroradiology