Marie Eman,  Oudjhane Kamaldine

Final Pr. ID: Paper #: 152

Neuroblastoma (NBL) is the most common extracranial solid malignancy of childhood. Biological features are known to affect disease severity. Status of amplification of the MYCN proto-oncogene is among several factors that affect the prognosis. CT texture analysis of tumor provides a step from qualitative to quantitative assessment, with the added bonus of use of routinely acquired images without the need for further tests. The aim of the study is to ascertain the ability to differentiate between MYCN-amplified and non MYCN-amplified neuroblastoma on pre-treatment CT images. The hypothesis is that lesion microenvironment and heterogeneity may differ significantly between MYCN-amplified and non MYCN-amplified tumor. Such differences may be exhibited in first-order texture analysis techniques that could detect more subtle differences in tumor heterogeneity by quantifying both pixel attenuation. This retrospective study objective is to explore the correlation between the first –order CT texture analysis (CTTA) and MYCN amplification status of neuroblastoma. Read More

Authors:  Marie Eman , Oudjhane Kamaldine

Keywords:  Neuroblastoma., CT texture., Radiomics