Joya Sosa Yocelin,  Madden Joseph,  Fadell Michael,  Carrico Caroline,  Maxfield Charles,  Cao Joseph

Final Pr. ID: Poster #: CR-026

Background:
Conventional medullary osteosarcoma is a malignant bone-forming tumor characterized by the production of osteoid matrix by malignant mesenchymal cells. Although it is the most common primary malignant bone tumor in children, primary osteosarcoma of the spine is exceptionally rare, accounting for less than 5% of pediatric osteosarcomas. Symptoms are frequently nonspecific, and early radiographic clues may be subtle. Due to its rarity and nonspecific presentation, spinal osteosarcomas are often diagnosed late, typically after structural destruction or neurologic compromise has occurred.

Case Report:
A 12-year-old female presented with two months of progressive low back pain and an unintentional 15-pound weight loss. She denied weakness, sensory loss, or bowel/bladder dysfunction. Lumbar spine radiographs revealed a lucency of the left L2 pedicle, producing a “winking owl sign.” Follow-up CT demonstrated a lytic, destructive lesion with asymmetric enlargement of the left psoas and paraspinal musculature. Additionally, CT was useful in demonstrating the presence of osseous matrix within the primary tumor. MRI revealed an expansile, enhancing lesion centered in the left posterior elements of L2, with paraspinal soft-tissue extension and circumferential epidural involvement causing moderate to severe canal stenosis. Biopsy confirmed the diagnosis of conventional medullary osteosarcoma. The patient remained neurologically intact and was referred for multidisciplinary oncologic management. Read More

Authors:  Joya Sosa Yocelin , Madden Joseph , Fadell Michael , Carrico Caroline , Maxfield Charles , Cao Joseph

Keywords:  Oncology, Osteosarcomas, Radiographic Findings

Kiru Louise,  Wu Wei,  Nejadnik Hossein,  Liu Anna,  Majzner Robbie,  Sulchek Todd,  Daldrup-link Heike

Final Pr. ID: Paper #: 154

Metastasized osteosarcoma has a poor prognosis with a two-year event free survival rate of 15-20%, highlighting the need for the advancement of efficacious therapeutics. Chimeric antigen receptor (CAR) T-cell therapy is emerging as a potent strategy for eliminating tumors by harnessing the immune system. Despite this, trials encounter challenges due to varied responses and failing therapy in patients. Development of translatable cell imaging methods would provide invaluable information regarding the biological fate of T-cells. This work aims to evaluate a new approach for CAR T-cell labeling with ferumoxytol, which enables non-invasive cell tracking with magnetic resonance imaging (MRI) and a new imaging technique, magnetic particle imaging (MPI). Read More

Authors:  Kiru Louise , Wu Wei , Nejadnik Hossein , Liu Anna , Majzner Robbie , Sulchek Todd , Daldrup-link Heike

Keywords:  Osteosarcoma, Chimeric antigen receptor T cells, Cell tracking