Gharavi Mohamad,  Record Jessica,  Vidal Lorenna,  Raghavan Prashant,  Morales Robert

Final Pr. ID: Poster #: EDU-086

Precocious puberty is defined as development of secondary sex characteristics before the age of 8 years in girls and 9 years in boys. Two types of precocious puberty have been recognized: central (CPP) and peripheral (PPP). The central precocious puberty is further divided into idiopathic or organic types. CNS imaging is indicated if CPP is diagnosed in boys at any age or in girls younger than 6 years.

Different structural abnormalities are associated with CPP such as Hypothalamic hamartoma, Hypothalamic astrocytoma, germ cell tumors or suprasellar arachnoid cysts.

The goals and objectives of the current presentation are as follow:

1- To briefly review the pathophysiology, clinical presentation and different types of CPP

2- To review the indications for CNS imaging work-up in children with CPP and to discuss the appropriate imaging modality and imaging protocol

3- To review different brain pathologies that are associated with CPP followed by discussion of main imaging characteristics through an interactive case series Read More

Authors:  Gharavi Mohamad , Record Jessica , Vidal Lorenna , Raghavan Prashant , Morales Robert

Keywords:  Central Precocious Puberty, Imaging

Rai Aayushi,  Gupta Rachita,  Setty Bindu

Final Pr. ID: Poster #: EDU-077

The pituitary gland, the epicenter of various regulatory hormones, plays an unquestionably important role in determining timely growth and sexual maturation. Indeed, multiple studies have examined the role of Growth Hormone (GH) and Gonadotrophic Releasing Hormone (GnRH) in treating delayed and precocious puberty respectively.[1]

Research has shown the importance of imaging the pituitary gland in patients with growth disturbances and/or documented endocrine abnormalities, in differentiating and classifying disorders based on etiology, prognosis and management.[2] Currently, data are limited in identifying a correlation between bone age abnormalities and pituitary findings via MRI, in children diagnosed with deviations in pubertal development. We present a comprehensive review of common structural abnormalities affecting the pituitary as seen on MRI – including developmental (dysgenesis/hypoplasia), traumatic, and neoplastic processes (both benign and malignant) – and how those pituitary lesions correlate with bone age and endocrine function in patients with growth failure and precocious puberty. Establishing a correlation between a patient’s endocrine profile, bone age and pituitary morphology on MRI imaging can be extremely useful in the judicious management of patients, in terms of patient selection, early diagnosis and treatment. Moreover, our review aims to highlight the importance of imaging in the workup of patients with known or suspected growth disturbances, illustrated via concept maps. The concordance of endocrine abnormalities and clinical information (including age, sex and ethnicity demographics) with imaging data will also be reviewed to demonstrate various patterns of disease presentation and diagnosis.

References:
[1] Du X.F., Yang X.H., Li J., Hao M., Guo Y.H. Growth hormone co-treatment within a gnrh agonist long protocol improves implantation and pregnancy rates in patients undergoing IVF-ET. Arch. Gynecol. Obstet. 2016;294:877–883. doi: 10.1007/s00404-016-4163-1.


[2] Di Iorgi N, Iorgi ND, Allegri AEM et al (2012) The use of neuroimaging for assessing disorders of pituitary development. Clin Endocrinol 76:161–176
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Authors:  Rai Aayushi , Gupta Rachita , Setty Bindu

Keywords:  Puberty, Pituitary abnormalities