Shore Matthew,  Riedesel Erica

Final Pr. ID: Poster #: EDU-128

Hepatic sinusoidal obstruction syndrome (SOS) - previously termed hepatic veno-occlusive disease (VOD) - is a serious cause of acute liver failure in patients undergoing hematopoietic cell transplantation (HCT).

Hepatic SOS results from injury to the hepatic venous endothelium during intensive myelopablative chemotherapy or radiation therapy prior to HCT. Endothelial injury eventually leads to fibrous obliteration of the terminal hepatic venules with sinusoidal obstruction, hepatocyte necrosis, and hemorrhage, typically seen in the first 3-6 weeks post-transplant.

Early identification of this disease process is critical given high incidence of multi-organ failure and significant morbidity and mortality. Ultrasound is extremely valuable in accurate early diagnosis as imaging findings often precede clinical signs of disease. Spectrum of findings on gray-scale ultrasound includes hepatomegaly, heterogeneous hepatic parenchymal echotexture, ascites, and gallbladder wall thickening. Findings on Doppler ultrasound - increased mean hepatic artery resistive index (RI) and decreased or reversed portal venous flow - are highly sensitivie for hepatic SOS.

In this education exhibit we will review the epidemiology and pathophysiology of hepatic sinusoidal obstruction syndreom (SOS) and discuss imaging findings that aid in accurate diagnosis. Special attention will be given to Doppler ultrasound findings and additional diagnostic information provided by B-flow Doppler ultrasound. Read More

Authors:  Shore Matthew , Riedesel Erica

Keywords:  Hepatic Sinusoidal Obstruction Syndrome, Doppler Ultrasound, B-flow Ultrasound, Educational Exhibit

Reddivalla Naresh,  Opfer Erin,  Robinson Amie,  Reid Kimberly,  Chan Sherwin

Final Pr. ID: Poster #: SCI-053

Sinusoidal obstruction syndrome (SOS) is a potentially fatal disease affecting children following bone marrow transplantation (BMT). SOS diagnosis is clinical because traditional ultrasound has poor sensitivity and specificity with portal vein flow reversal occurring well after the disease is clinically evident. Ultrasound elastography is a newer technology that measures liver stiffness, which should increase in SOS due to passive hepatic congestion. Our hypothesis is that quantitative shear wave ultrasound elastography will be more accurate in detecting this disease compared with conventional ultrasound parameters. Read More

Authors:  Reddivalla Naresh , Opfer Erin , Robinson Amie , Reid Kimberly , Chan Sherwin

Keywords:  Sinusoidal Obstruction Syndrome, Veno-Occlusive Disease, Ultrasound Elastography