Ulikowska Ewelina

Final Pr. ID: Poster #: EDU-012 (T)

Langerhans Cell Histiocytosis (LCH), is a disorder that primarily affects children, but can affect individuals of all ages. Langerhans cells are cells that are responsible for regulating immune system in our bodies. They are mostly found in the skin, spleen, lymph nodes, liver and bone marrow. In patients who have LCH, these cells grow and multiply excessively. The abnormal growth of the Langerhans cells causes a formation of tumors called granulomas. LCH can affect different areas of the body: skin, nails, lymph nodes, gastrointestinal tract, central nervous system, pituitary and thyroid gland, liver, lungs and bones. The severity and symptoms of the disease vary in individual patients and are dependent on the organs and systems affected. Oftentimes, LCH can be found in multiple areas of the body and when that happens, the disease becomes a multisystem disease. The most common system affected by LCH, seen in about 80 % of individuals affected, is the skeletal system. Granulomas, which develop most commonly in the flat bones such as skull and long bones of arms and legs, cause sclerotic and lytic lesions that can in turn become the cause of pathologic fractures. Therefore it is crucial, to recognize the radiographic signs of skeletal manifestations of LCH. Radiography is the preliminary imaging of choice and skeletal surveys are oftentimes the best assessment of the status of LCH prior and post treatment. The purpose of this abstract is to describe radiographic appearances associated with Langerhans Cell Histiocytosis. In order to confirm the importance of follow up skeletal surveys, I will present cases and associated radiographs that show signs of LCH prior to treatment and post treatment. Read More

Authors:  Ulikowska Ewelina

Keywords:  Langerhans Cell Histiocytosis, Radiographic findings, Skeletal manifestations

Henderson Brandon,  Mccollum Samuel,  Brahee Deborah

Final Pr. ID: Poster #: EDU-076

Pediatric sternal lesions encompass a broad constellation of diagnoses, many of which carry a high level of clinical significance. The purpose of this exhibit is to review sternal development and a diverse array of pediatric sternal lesions across multiple modalities in order to (1) assist the clinical radiologist in identifying these diagnoses, (2) highlight a class of entities (sternal lesions) which is easily overlooked, and (3) provide a simple and practical mental framework for categorizing these entities. This exhibit explores multi-modality imaging examples in a variety of interesting cases obtained through a retrospective review at a large quaternary care center. The relevant clinical features and key imaging findings for each diagnosis are discussed to educate radiologists and radiology residents, aiming to improve diagnosis and patient outcomes. Cases discussed include congenital variations in development (pectus excavatum and pectus carinatum), traumatic sternal fracture, neoplastic etiologies (SELSTOC, Ewing Sarcoma, B-Cell Acute Lymphoblastic Leukemia, and metastatic disease), as well as infectious/inflammatory presentations (sternal osteomyelitis, abscess, and chronic recurrent multifocal osteomyelitis). Read More

Authors:  Henderson Brandon , Mccollum Samuel , Brahee Deborah

Keywords:  Sternum, Image Findings, Skeletal Manifestations