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Final ID: Paper #: 130

Evaluating the correlation between doppler ultrasound parameters and invasive hemodynamic measurements in a pediatric porcine model of asphyxia-associated cardiac arrest

Purpose or Case Report: The purpose of this experiment was to evaluate the correlation between the doppler and intracranial pressure (ICP) and mean arterial pressure (MAP) in a pediatric porcine model of asphyxia-associated cardiac arrest.
Methods & Materials: In 5 infant piglets, 5 doppler samplings of thalamic vessels were taken during 10 minutes pre-asphyxia (baseline) and 3 hours post-return of spontaneous circulation (ROSC). Invasive hemodynamic measurements ICP and MAP were collected continuously and later normalized to the baseline. Average relative changes of ICP, TTP, and doppler ultrasound parameters (peak systolic velocity and end diastolic velocity) were compared baseline measurements to measurements at 3 hours post-ROSC.
Results: The average of peak systolic velocity at baseline was 14.01 cm/s and at 3 hours post-ROSC was 15.03 cm/s. The average of end diastolic velocity at baseline was 7.11 cm/s and at 3 hours post-ROSC was 3.73 cm/s. The average of normalized ICP at baseline was 0.97 a.u. and at 3 hours post-ROSC was 1.26 a.u.. The average of the normalized MAP at baseline was 1.01 a.u. and at 3 hours post-ROSC was 1.12 a.u.. The difference between values at baseline and 3 hours post-ROSC for all parameters are statistically insignificant (p=0.60, p=0.75, p=0.47, and p = 0.11 for peak systolic velocity, end diastolic velocity, MAP, and ICP respectively). Both peak systolic velocity and end diastolic velocity had a negative linear correlation with MAP, both with Pearson coefficients of -0.86. The variation in peak systolic velocity and end diastolic velocity that is relative to the variation in MAP is 74.0%. There was no significant linear correlation between peak systolic velocity or end diastolic velocity with ICP, with a Pearson coefficient of -0.01 for peak systolic velocity and a coefficient of -0.13 for end diastolic velocity. The variation in peak systolic velocity and end diastolic velocity that is relative to the variation in ICP is 1.7%.
Conclusions: This preliminary investigation reveals that the end diastolic velocity and peak systolic velocity is correlated with MAP, but not ICP, indicating that both parameters can be used to noninvasively predict MAP changes. Doppler ultrasound has less risk associated with it than invasive hemodynamic measurements, offering a safer alternative method.
  • Khaw, Kristina  ( University of Pennsylvania , Plainsboro , New Jersey , United States )
  • Sridharan, Anush  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
  • Poznick, Laura  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
  • Kilbaugh, Todd  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
  • Hwang, Misun  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
Session Info:

Scientific Session V-B: Neuroradiology

Neuroradiology

SPR Scientific Papers

More abstracts from these authors:
Evaluating the correlation between bolus perfusion kinetics using contrast-enhanced ultrasound and intracranial pressure in a pediatric porcine model of asphyxia-associated cardiac arrest

Khaw Kristina, Sridharan Anush, Poznick Laura, Kilbaugh Todd, Hwang Misun

Application of Contrast-enhanced Ultrasonography and Shear Wave Elastography for Evaluation of Thyroid Nodules with Biopsy Correlation: Early Experience in Children

Smitthimedhin Anilawan, Krishnamurthy Ganesh, Sridharan Anush, Poznick Laura, Durand Rachelle, Whitaker Jayme, Escobar Fernando, Bauer Andrew, Cahill Anne Marie

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