Main Logo
Logo

Society for Pediatric Radiology – Poster Archive

  127
  0
  0
 
 


Final ID: Paper #: 129

Evaluating the correlation between bolus perfusion kinetics using contrast-enhanced ultrasound and intracranial pressure in a pediatric porcine model of asphyxia-associated cardiac arrest

Purpose or Case Report: The purpose of this experiment was to evaluate the correlation between the doppler and intracranial pressure (ICP) and mean arterial pressure (MAP) in a pediatric porcine model of asphyxia-associated cardiac arrest.
Methods & Materials: In 6 infant piglets, a bolus of 0.1 dose mL of ultrasound contrast (Lumason, Bracco Diagnostics Inc) was injected into swine during 10 minutes pre-asphyxia (baseline) and 3 hours post-return of spontaneous circulation (ROSC). During each period, 2-3 boluses were performed. Early washout rates were acquired when CEUS intensities of the bolus was 30% of the maximum intensity. In addition, Time to peak (TTP) and peak enhancement were measured. ICP was collected continuously and later normalized to the baseline. Average relative changes of ICP, TTP, early washout rate, and peak enhancement from baseline to 3 hours post-ROSC were compared.
Results: The average of peak systolic velocity at baseline was 14.01 cm/s and at 3 hours post-ROSC was 15.03 cm/s. The average of end diastolic velocity at baseline was 7.11 cm/s and at 3 hours post-ROSC was 3.73 cm/s. The average of normalized ICP at baseline was 0.97 a.u. and at 3 hours post-ROSC was 1.26 a.u.. The average of the normalized MAP at baseline was 1.01 a.u. and at 3 hours post-ROSC was 1.12 a.u.. The difference between values at baseline and 3 hours post-ROSC for all parameters are statistically insignificant (p=0.60, p=0.75, p=0.47, and p = 0.11 for peak systolic velocity, end diastolic velocity, MAP, and ICP respectively). Both peak systolic velocity and end diastolic velocity had a negative linear correlation with MAP, both with Pearson coefficients of -0.86. The variation in peak systolic velocity and end diastolic velocity that is relative to the variation in MAP is 74.0%. There was no significant linear correlation between peak systolic velocity or end diastolic velocity with ICP, with a Pearson coefficient of -0.01 for peak systolic velocity and a coefficient of -0.13 for end diastolic velocity. The variation in peak systolic velocity and end diastolic velocity that is relative to the variation in ICP is 1.7%.
Conclusions: This preliminary investigation reveals that the early washout rate, but not TTP or peak enhancement, is strongly correlated with ICP, indicating that the bolus-based early washout rate change can be used to predict ICP changes. CEUS intensity has less risk associated with it than invasive hemodynamic measurements such as ICP, offering a safer alternative method.
  • Khaw, Kristina  ( University of Pennsylvania , Plainsboro , New Jersey , United States )
  • Sridharan, Anush  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
  • Poznick, Laura  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
  • Kilbaugh, Todd  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
  • Hwang, Misun  ( Children's Hospital of Philadelphia , Philadelphia , Pennsylvania , United States )
Session Info:

Scientific Session V-B: Neuroradiology

Neuroradiology

SPR Scientific Papers

More abstracts on this topic:
Renal Perfusion Changes Pre- and Post- renal Artery Angioplasty: Early Quantitative Experience Using Contrast-enhanced US in Children

Smitthimedhin Anilawan, Sridharan Anush, Darge Kassa, Back Susan, Cahill Anne Marie

Feasibility of Intracranial Contrast-Enhanced Ultrasound in Neonates: Comparison with MRI

Squires Judy, Beluk Nancy, Yanowitz Toby, Kephart Morie, Panigrahy Ashok

More abstracts from these authors:
Application of Contrast-enhanced Ultrasonography and Shear Wave Elastography for Evaluation of Thyroid Nodules with Biopsy Correlation: Early Experience in Children

Smitthimedhin Anilawan, Krishnamurthy Ganesh, Sridharan Anush, Poznick Laura, Durand Rachelle, Whitaker Jayme, Escobar Fernando, Bauer Andrew, Cahill Anne Marie

Evaluating the correlation between doppler ultrasound parameters and invasive hemodynamic measurements in a pediatric porcine model of asphyxia-associated cardiac arrest

Khaw Kristina, Sridharan Anush, Poznick Laura, Kilbaugh Todd, Hwang Misun

Preview
Paper____129.pdf
You have to be authorized to contact abstract author. Please, Login or Signup.

Please note that this is a separate login, not connected with your credentials used for the SPR main website.

Not Available

Comments

We encourage you to join the discussion by posting your comments and questions below.

Presenters will be notified of your post so that they can respond as appropriate.

This discussion platform is provided to foster engagement, and stimulate conversation and knowledge sharing.

Please click here to review the full terms and conditions for engaging in the discussion, including refraining from product promotion and non-constructive feedback.

 

You have to be authorized to post a comment. Please, Login or Signup.

Please note that this is a separate login, not connected with your credentials used for the SPR main website.


   Rate this abstract  (Maximum characters: 500)