Mowrer Gregory,  Jaramillo Diego,  Restrepo Ricardo,  Imundo Lisa,  Flemming Don,  Chauvin Nancy

Final Pr. ID: Poster #: EDU-038

Chronic nonbacterial osteomyelitis (CNO) is an aseptic auto-inflammatory condition that affects children and presents with insidious bone pain. Children present with a variable clinical spectrum of disease with either unifocal or multifocal pain and acute (duration < 6months) or chronic (>6 months) symptoms. The disease course may be recurrent. In some cases, patients endure multiple lesions over a course of exacerbations and remissions. Bone lesions are often in symmetrical regions. Interestingly, clinically asymptomatic bone lesions are discovered during the imaging evaluation. Patient symptoms and clinical course may mimic other diseases, making CNO often difficult to diagnose with a consequent delay in diagnosis. Children with CNO may also develop arthritis and demonstrate similar cytokine profiles with children with juvenile idiopathic arthritis (JIA), suggesting at least a partial common disease pathway. Read More

Authors:  Mowrer Gregory , Jaramillo Diego , Restrepo Ricardo , Imundo Lisa , Flemming Don , Chauvin Nancy

Keywords:  chronic nonbacterial osteomyelitis, osteitis, CRMO

Aboughalia Hassan,  Iyer Ramesh

Final Pr. ID: Poster #: EDU-043

Chronic recurrent multifocal osteomyelitis (CRMO) is a relatively new autoinflammatory pediatric musculoskeletal diagnosis. It was first discovered by Giedion et al 1972, who described “an unusual form of multifocal bone lesions with subacute and chronic symmetrical osteomyelitis”. CRMO can be a problematic diagnosis due to its variable presentation. Clinical, laboratory, and imaging findings must be aggregated to arrive at a CRMO diagnosis. Imaging plays a central role in CRMO diagnosis and management. Typical imaging findings that are generally but not necessarily multifocal, and exhibit changes over time, are crucial to CRMO management plan.
Many pathologic entities can mimic CRMO because of its diverse clinical and imaging manifestations. These conditions include infectious processes such as septic arthritis and osteomyelitis, other inflammatory conditions such as psoriatic arthritis, metabolic disturbances such as rickets and scurvy, traumatic injuries such as acute fractures and osteonecrosis from repetitive microtrauma, neoplastic entities such as metastasis and lymphoma, and neoplastic-like entities like Langerhans cell histiocytosis. In our exhibit, we will review the classic imaging manifestations of CRMO and present a spectrum of lesions in which CRMO was an initial consideration, but ultimately proved to be a different pathology.
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Authors:  Aboughalia Hassan , Iyer Ramesh

Keywords:  CRMO, Mimickers

Sato T Shawn,  Bajaj Manish,  Ferguson Polly

Final Pr. ID: Poster #: EDU-085

Chronic Recurrent Multifocal Osteomyelitis (CRMO) is a multifocal auto-inflammatory disease that has gained increased recognition in recent years. Because CRMO is a diagnosis of exclusion, clinical history and imaging findings are important in suggesting a diagnosis. While imaging features of CRMO have been described, other disease processes can have a similar appearance to CRMO. We review some diseases that can mimic the radiographic appearance of CRMO and discuss features that can suggest alternative diagnoses. Read More

Authors:  Sato T Shawn , Bajaj Manish , Ferguson Polly

Keywords:  CRMO, MRI, Lymphoma

Sato T Shawn,  Bajaj Manish,  Ferguson Polly

Final Pr. ID: Poster #: EDU-058

Chronic Recurrent Multifocal Osteomyelitis (CRMO) is an auto-inflammatory disease that can affect multiple locations. Whole body MRI is an important tool to help identify subclinical multifocal disease and help monitor disease. As a referral center for CRMO, we have developed a successful CRMO whole body MRI imaging protocol which maximizes diagnostic information while minimizing scanner time. Read More

Authors:  Sato T Shawn , Bajaj Manish , Ferguson Polly

Keywords:  Rheumatology, CRMO, Whole Body MRI