Chronic nonbacterial osteomyelitis (CNO) is an aseptic auto-inflammatory condition that affects children and presents with insidious bone pain. Children present with a variable clinical spectrum of disease with either unifocal or multifocal pain and acute (duration < 6months) or chronic (>6 months) symptoms. The disease course may be recurrent. In some cases, patients endure multiple lesions over a course of exacerbations and remissions. Bone lesions are often in symmetrical regions. Interestingly, clinically asymptomatic bone lesions are discovered during the imaging evaluation. Patient symptoms and clinical course may mimic other diseases, making CNO often difficult to diagnose with a consequent delay in diagnosis. Children with CNO may also develop arthritis and demonstrate similar cytokine profiles with children with juvenile idiopathic arthritis (JIA), suggesting at least a partial common disease pathway.
SPR 2020 Annual Meeting & Postgraduate Course
chronic nonbacterial osteomyelitis,