Hill Ann,  Hirsig Leslie,  Yazdani Milad,  Collins Heather,  Jenkins Dorothea

Final Pr. ID: Poster #: SCI-015

MRS is the best prognostic indicator for hypoxic-ischemic encephalopathy (HIE) but is difficult to obtain early after injury. We investigated whether cerebral blood flow measures of resistive indices (RI) and time average maximum velocities (TAMx) shortly after birth would relate to later degree of neural injury by MRI in hypothermic HIE newborns. We predicted that abnormally high/low blood flow would be associated with poor outcomes. Read More

Authors:  Hill Ann , Hirsig Leslie , Yazdani Milad , Collins Heather , Jenkins Dorothea

Keywords:  Cerebral Blood Flow, Hypoxic Ischemic Encephalopathy (HIE), Magnetic Resonance Spectroscopy (MRS)

Le Phong,  Leschied Jessica,  Ledbetter Karyn

Final Pr. ID: Poster #: EDU-014

Hypoxic ischemic encephalopathy occurs in up to 1.5-2.5 per 1,000 live births in developed countries and can result in major neurologic deficits and mortality in the neonatal population. Currently, treatments are supportive and include moderate hypothermia which has demonstrated a significant reduction in disability and mortality in patients with moderate hypoxic ischemic encephalopathy. Despite improved mortality, morbidity in this patient population remains high with residual neurological deficits. This review will illustrate the patterns of brain injury as well as the imaging findings of neonatal hypoxic ischemic injury on ultrasound, CT, and MRI to assist with diagnosis and prognosis.
By completion of this exhibit, the learner will:
1. Review the anatomy of the neonatal brain on multiple modalities include ultrasound, CT, and MRI.
2. Be familiar with the patterns of brain injury in neonates.
3. Be able to identify the sonographic, CT, and MRI findings of neonatal hypoxic ischemic encephalopathy.
4. Understand the treatments and prognosis for neonatal hypoxic encephalopathy. Read More

Authors:  Le Phong , Leschied Jessica , Ledbetter Karyn

Keywords:  HIE

Vyas Rutvi,  Morton Sarah,  Nunes Deivid,  Song Yanan,  Grant Ellen,  Ou Yangming

Final Pr. ID: Paper #: 119

Hypoxic Ischemic Encephalopathy (HIE) occurs in 1-6/1000 livebirths often leading to death or neurological disability. Neonatal brain magnetic resonance imaging (MRI) is used to assess severity of brain injury and provide prognostic information in the newborn period. However, 20-50% HIE patients do not have early abnormal MRI findings detected by qualitative neuroradiologic evaluation and yet have adverse outcomes evident by 2 years of age. Our aim was to investigate whether quantitative MRI analysis can find subtle abnormalities that help improve prognostication and reduce the incidence of falsely reassuring neonatal MRI among infants with HIE. Read More

Authors:  Vyas Rutvi , Morton Sarah , Nunes Deivid , Song Yanan , Grant Ellen , Ou Yangming

Keywords:  HIE, neonates, Quantitative MRI