Showing 6 Abstracts.
Lankester Evelyn, Graeber Brendon
Final Pr. ID: Poster #: EDU-038
Chronic non-infectious osteomyelitis (CNO) is an autoinflammatory disorder of unknown etiology that is characterized by sterile, painful, and destructive bone lesions and has its peak incidence in childhood. Its presentation can be highly variable, and when children present with solitary lesions having an indolent course, the clinical picture and imaging features at presentation can overlap with those of Ewing sarcoma (EWS), a rare, highly malignant, primary pediatric bone tumor with a poor prognosis. Osteomyelitis is a known imaging mimic of EWS, but CNO poses a particular problem because a lack of clinical markers usually indicative of infection can cause the disease to be mistaken for a malignancy at clinical workup as well as imaging. A misdiagnosis between these two diseases may have serious repercussions for treatment and clinical course with potentially devastating effects on patient outcomes. Read More
Authors: Lankester Evelyn , Graeber Brendon
Keywords: CNO, Ewing´s Sarcoma
Kryger Marc, Hernandez Alejandra, Herring Katye, Riegler Lara, Hook Marcus, Daugherty Reza
Final Pr. ID: Poster #: CR-028
A 16 year old boy reporting several months of hip pain, weight-loss, and fatigue presented to our institution after a pelvis radiograph ordered by his family physician showed concerning findings. MR imaging of his pelvis demonstrated a large heterogeneously enhancing mass arising from the right iliac wing causing significant mass effect on the pelvic organs and soft tissues of the buttocks. A percutaneous biopsy confirmed the diagnosis of Ewing sarcoma.
A staging CT of the chest was performed, demonstrating multiple lung metastases. In addition to this finding, there was multifocal bilateral nodular tumor thrombus propagating along multiple subsegmental pulmonary arteries, with a pseudo tree-in-bud morphology. Given their course, these metastatic deposits appeared endovascular in origin.
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Authors: Kryger Marc , Hernandez Alejandra , Herring Katye , Riegler Lara , Hook Marcus , Daugherty Reza
Keywords: Ewing, Sarcoma, Metastasis
Final Pr. ID: Poster #: SCI-016
To see the profile of various Pediatric Abdominal Mass Lesions on MDCT and to evaluate the diagnostic accuracy of MDCT in detection and characterization of various Pediatric Abdominal Mass Lesions. Read More
Authors: Yadava Rohtas
Keywords: Hepatoblastoma, Ewing Sarcoma, Adrenal Pheochromocytoma
To Evaluate the Role of 18F-FDG PET/CT Versus Conventional Imaging for Initial Staging and Follow-Up of Pediatric Sarcomas
Final Pr. ID: Poster #: SCI-025
The purpose of this study was to compare the diagnostic performance of 18F-FDG PET/CT and conventional imaging for staging and follow-up of pediatric osteosarcoma and skeletal Ewing sarcoma. Read More
Authors: Shaikh Sikandar
Keywords: Sarcoma
Shah Avanthi, Alizadeh Ash, Sweet-cordero Alejandro, Wittber Frederick, Azad Tej, Chabon Jake, Leung Stan, Spillinger Aviv, Liu Heng-yi, Breese Marcus, Diehn Maxamilian
Final Pr. ID: Poster #: SCI-061
Currently, biopsy serves as the gold standard to accurately diagnose disease in pediatric sarcoma patients, but the risks of anesthesia and surgery, along with a failure to characterize the true heterogeneity of disease make this method less than ideal. Progression and response to therapy are monitored by radiologic exams which lack the sensitivity to detect early relapse. Cell free DNA (cfDNA) is released into the plasma as they undergo apoptosis and necrosis. ctDNA represents a small fraction of cfDNA in cancer patients and contains tumor specific alterations. It holds promise as a highly sensitive and specific biomarker. A limitation in applying liquid biopsy in clinical practice is the need to develop PCR or other DNA analysis methods to detect alterations specific to a single patient. We have developed a more widely applicable off the shelf test that does not involve a patient specific design. Read More
Authors: Shah Avanthi , Alizadeh Ash , Sweet-cordero Alejandro , Wittber Frederick , Azad Tej , Chabon Jake , Leung Stan , Spillinger Aviv , Liu Heng-yi , Breese Marcus , Diehn Maxamilian
Cross Nathan, Stanescu A. Luana, Rudzinski Erin, Hawkins Doug, Parisi Marguerite
Final Pr. ID: Poster #: CR-057
Ewing sarcoma is the second most common malignancy of bone with an incidence of approximately 200 cases per year in the United States in children under 20. Extraosseous Ewing sarcoma originating in the vagina is rare, with only 8 cases reported to date in the literature. These highly aggressive tumors require a more intensive treatment regimen compared to other vaginal masses like rhabdomyosarcoma. While the imaging findings are non-specific, awareness of this clinical entity can facilitate early diagnosis and appropriate treatment, which may improve prognosis. Read More
Authors: Cross Nathan , Stanescu A. Luana , Rudzinski Erin , Hawkins Doug , Parisi Marguerite