Children with Duchene muscular dystrophy (DMD) have increased risk for osteoporosis and fragility fractures due to progressive muscle weakness with eventual loss of ambulation and chronic corticosteroid therapy. Their fracture prevalence is 40-60%, and increases with age. Bone Mineral Density (BMD) is not reflective of fracture risk. Recent studies showed that cortical thickness and area were associated with increased facture risk. Digital X-ray measurement of the cortical thickness of the metacarpal bones can be used as a marker for metacarpal cortical health. To our knowledge, this marker of bone health has not been evaluated in DMD patients. The purpose of this study was to assess bone age (BA), cortical thickness and area of metacarpal bones in relation to age in children with DMD. Read More

Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019

Authors: Bowden Jonathan, Bowden Sasigarn, Adler Brent, Hu Houchun, Krishnamurthy Rajesh, Krishnamurthy Ramkumar

Keywords: Bone health, DMD, Duchenne