Vasyliv Iryna

Final Pr. ID: Poster #: SCI-067

Chimeric antigen receptor (CAR) T-cell therapy achieves remission in 80–90% of children with relapsed or refractory acute lymphoblastic leukemia (ALL), but only 20% in pediatric patients with solid tumors. Identifying early biomarkers of response could allow timely interventions for non-responders and support the optimization of effective combination therapies. The spleen plays a central role in immune regulation and lymphocyte trafficking, potentially affecting CAR T-cell expansion, persistence, and toxicity risk. The purpose of our study was to explore if pre treatment spleen to liver SUV ratio (SLR) measured on 18FDG PET/MR may correlate with their treatment outcomes. Read More

Authors:  Vasyliv Iryna

Keywords:  Immunotherapy, Outcomes, Hybrid Pet/MRI

Devkota Laxman,  Bhavane Rohan,  Badachhape Andrew,  Veeramachaneni Ratna,  Stupin Igor,  Bhandari Prajwal,  Ghaghada Ketan,  Sikora Andrew,  Annapragada Ananth

Final Pr. ID: Paper #: 153

The incidence of head and neck malignancies among children has increased substantially in the last five decades. The immunosuppressive tumor micro-environment (TME) represents a major roadblock in the treatment of head and neck tumors. We have demonstrated previously that an elevated level of myeloid derived suppressor cells (MDSC) in the tumor correlates directly with a poor prognosis, and that MDSC levels can be reduced using inhibitors of inducible nitric oxide synthase (iNOS). In this pre-clinical study, we utilized non-contrast magnetic resonance imaging (MRI) and nanoparticle contrast-enhanced computed tomography (CECT) to monitor tumor responses to TME-directed combinatorial therapies that included iNOS inhibition, immunomodulation, checkpoint inhibition, and radiation. Read More

Authors:  Devkota Laxman , Bhavane Rohan , Badachhape Andrew , Veeramachaneni Ratna , Stupin Igor , Bhandari Prajwal , Ghaghada Ketan , Sikora Andrew , Annapragada Ananth

Keywords:  Immunotherapy, Tumor, Imaging