Devkota Laxman,  Bhavane Rohan,  Badachhape Andrew,  Veeramachaneni Ratna,  Stupin Igor,  Bhandari Prajwal,  Ghaghada Ketan,  Sikora Andrew,  Annapragada Ananth

Final Pr. ID: Paper #: 153

The incidence of head and neck malignancies among children has increased substantially in the last five decades. The immunosuppressive tumor micro-environment (TME) represents a major roadblock in the treatment of head and neck tumors. We have demonstrated previously that an elevated level of myeloid derived suppressor cells (MDSC) in the tumor correlates directly with a poor prognosis, and that MDSC levels can be reduced using inhibitors of inducible nitric oxide synthase (iNOS). In this pre-clinical study, we utilized non-contrast magnetic resonance imaging (MRI) and nanoparticle contrast-enhanced computed tomography (CECT) to monitor tumor responses to TME-directed combinatorial therapies that included iNOS inhibition, immunomodulation, checkpoint inhibition, and radiation. Read More

Authors:  Devkota Laxman , Bhavane Rohan , Badachhape Andrew , Veeramachaneni Ratna , Stupin Igor , Bhandari Prajwal , Ghaghada Ketan , Sikora Andrew , Annapragada Ananth

Keywords:  Immunotherapy, Tumor, Imaging