Mousa Abeer,  Fox Lauren,  Simmons Curtis

Final Pr. ID: Poster #: CR-058

We present a case of an 11-year-old male with history of pars planitis (intermediate uveitis) on monthly infliximab and weekly methotrexate. The patient developed diffuse lymphadenopathy, predominantly in the head and neck region, raising suspicion for malignancy. CT of the neck and chest demonstrated enlarged cervical, upper mediastinal , and bilateral axillary lymph nodes. PET/CT confirmed prominent FDG uptake in these lymph nodes. A lymph node biopsy of a parotid lymph node confirmed Epstein Barr virus-positive polymorphic lymphoproliferative disorder in the setting of immune deficiency/dysregulation. Follow up PET/CT 2 months later after discontinuation of immunosuppressive therapy demonstrated significant improvement in size and radiotracer uptake of the enlarged lymph nodes. However within this time frame, the patient’s uveitis worsened. The patient is being followed by ophthalmology to explore other localized treatment options including steroid eye drops and steroid implants.
The majority of described findings in the radiology literature encompasses lymphoproliferative disorders in the setting of transplant (post-transplant lymphoproliferative disorder (PTLD)) or primary immunodeficiency. However, there is little in the way of lymphoproliferative disorders associated with immunosuppressive therapy. Most cases reported in the literature involve methotrexate use in adults with rheumatoid arthritis. Prior to 2022, this entity held a WHO classification entitled “other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OII-LPD)”. Following a 2022 WHO reclassification, both PTLD and OII-LPD are encompassed under the classification of “lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation". Further research on imaging of OII-LPD would add to the existing literature and increase awareness of such an entity in the setting of immunosuppressive therapy. Read More

Authors:  Mousa Abeer , Fox Lauren , Simmons Curtis

Keywords:  Lymphoproliferative, PTLD, Lymphadenopathy

Kennedy Patrick,  Baad Michael,  Kovanlikaya Arzu,  Cohen Sara,  Collins Lee,  Pomeranz Christy

Final Pr. ID: Poster #: EDU-029

Langerhans cell histiocytosis (LCH) is rare in the neonatal period and has a different distribution of disease and prognosis compared to older cohorts, requiring extensive imaging evaluation and familiarity of the radiologist with potential sites of involvement. Treatment and prognosis is dependent on accurate pretreatment evaluation. In this educational poster, we first describe histiocystic disorders, the current and prior classification schema, and the role of imaging in pretreatment evaluation of LCH. Utiliziing cases at our institution, we explore the imaging findings in neonatal LCH organized by organ system and the role of imaging in risk organ identification. We discuss the affect on treatment and prognosis, and the differences in imaging and prognosis between neonatal presentation and other age groups. Finally, we review current guidelines for posttreatment imaging follow up. Read More

Authors:  Kennedy Patrick , Baad Michael , Kovanlikaya Arzu , Cohen Sara , Collins Lee , Pomeranz Christy

Keywords:  Neonatal, lymphoproliferative, neoplasia

Lucin Michael,  Faruqui Sami,  Watal Pankaj,  Sato Yutaka,  Price Nathan,  Sato T Shawn

Final Pr. ID: Poster #: EDU-096

In the pediatric population, lymphadenopathy may be caused by a variety of diseases including lymphoma. Accurate differentiation of a non-lymphomatous lymphoproliferative disorder from lymphoma and other lymphoproliferative disorders is important in determining appropriate management. Radiologic imaging including assessment of cervical, mediastinal, and hilar lymphadenopathy can often provide the critical clue needed for accurate diagnosis. Read More

Authors:  Lucin Michael , Faruqui Sami , Watal Pankaj , Sato Yutaka , Price Nathan , Sato T Shawn

Keywords:  Lymphadenopathy, Lymphoproliferative

Samreen Naziya,  Sharma Priya,  Tuna Ibrahim,  Rajderkar Dhanashree

Final Pr. ID: Poster #: EDU-113

1. To establish the role of imaging in diagnosing the atypical/unexpected cases of post transplant lymphoproliferative disorder in Pediatric population.
2. To review the role of Radiology Imaging in staging, treatment monitoring and predicting the prognosis in Pediatric PTLD. Read More

Authors:  Samreen Naziya , Sharma Priya , Tuna Ibrahim , Rajderkar Dhanashree

Keywords:  Transplant, Lymphoproliferative, PTLD, Unexpected, Management of PTLD