Langerhans cell histiocytosis (LCH) is rare in the neonatal period and has a different distribution of disease and prognosis compared to older cohorts, requiring extensive imaging evaluation and familiarity of the radiologist with potential sites of involvement. Treatment and prognosis is dependent on accurate pretreatment evaluation. In this educational poster, we first describe histiocystic disorders, the current and prior classification schema, and the role of imaging in pretreatment evaluation of LCH. Utiliziing cases at our institution, we explore the imaging findings in neonatal LCH organized by organ system and the role of imaging in risk organ identification. We discuss the affect on treatment and prognosis, and the differences in imaging and prognosis between neonatal presentation and other age groups. Finally, we review current guidelines for posttreatment imaging follow up. Read More

Meeting name: SPR 2024 Annual Meeting & Postgraduate Course , 2024

Authors: Kennedy Patrick, Baad Michael, Kovanlikaya Arzu, Cohen Sara, Collins Lee, Pomeranz Christy

Keywords: Neonatal, lymphoproliferative, neoplasia