Final Pr. ID: Poster #: CR-021
Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder of abnormal proliferation of Langerhans cells affecting predominantly pediatric populations; sites of involvement include cutaneous, osseous, hematopoietic, and multisystem disease (1). Cutaneous involvement is common in children, though thymic involvement is rarely described (2). We report a case of an 8-month-old female infant with a dyad of cutaneous and thymic LCH. The purpose of this paper is to highlight a potentially underdiagnosed manifestation of infantile LCH and consider thymic sonography in infant LCH staging evaluation.
A one-month old female presented with skin lesions and pruritus suspicious for atopic dermatitis failing to respond to therapy. Punch biopsy demonstrated cutaneous LCH. Staging non-contrast chest computed tomography (CT) showed multiple very faint calcifications in the thymus (figure 1) which could have been obscured by intravenous contrast administration. Ultrasound demonstrated multiple echogenic foci in the thymus (figure 2). Pathology confirmed thymic LCH. Throughout her presentation, the patient’s clinical symptoms of LCH were limited to diffuse pruritic cutaneous lesions. Thymic involvement changed patient management to chemotherapy infusion. At the time of this report she has shown no signs of disease progression and she remains clinically stable. Read More
Final Pr. ID: Poster #: EDU-008
The imaging characteristics of ectopic thymus will demonstrated on ultrasound and MRI. These imaging characteristics and the embryonal migration of the thymus will be illustrated with biopsied proven examples of ectopic thymus. Characteristic physical examination correlation is provided. The importance of confirming the precence or absence of thymus in the mediastinum is highlighted. A pictorial essay will be provided.
Final Pr. ID: Poster #: EDU-078
The pediatric thymus is a constant but confusing, dynamic entity. The goal of this educational exhibit is to illustrate the range of appearances of the normal thymus and to identify key imaging features that can help pediatric radiologists differentiate normal thymic tissue from neoplastic conditions and other mimics. Read More
Final Pr. ID: Poster #: EDU-033
The Thymus appears in a variety of sizes and shapes, and may even change in size as a response to disease process in the same patient. These underlying variations, as well as ectopic or accessory tissue, can mimic pathology and may become a source of confusion resulting in anxiety, unwarranted imaging, unnecessary biopsy, chemoradiation or even surgery. Read More