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Society for Pediatric Radiology – Poster Archive

Lillian Lai

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Showing 5 Abstracts.

The purpose of this exhibit is explore pitfalls in our experience with SPECT-CT Iodine-123 (I-123) MIBG imaging in patients with neuroblastoma. SPECT-CT can more specifically localize areas of uptake over planar imaging and mitigate false-positive results with correlative anatomic information. We will review cases of false-positive MIBG uptake in nonmalignant sites, cases of false-negative MIBG uptake in neuroblastoma/neural crest tumors, and cases of secondary tumors/malignancies occurring in the setting of known neuroblastoma, with variable uptake on MIBG. Read More

Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019

Authors: Lai Lillian, Berkovich Rachel, Goodarzian Fariba

Keywords: MIBG, neuroblastoma, SPECT-CT

Review the unique features of pediatric oncologic emergencies using case review of neurological, spinal, thoracic and abdominal pathologies, covering complications due to the malignancy or its treatment. Read More

Meeting name: IPR 2016 Conjoint Meeting & Exhibition , 2016

Authors: Sato T Shawn, Lai Lillian, Sato Yutaka

Keywords: Pediatric, Oncologic, Tumor, Emergency, Radiology

The goal of this educational exhibit is to explore the utility of interictal FDG PET brain imaging in the evaluation of intractable, drug-resistant cases of pediatric epilepsy and to clarify its role in pre-surgical seizure focus localization. We will also explore the salient pearls and pitfalls of FDG PET brain imaging. Read More

Meeting name: SPR 2018 Annual Meeting & Postgraduate Course , 2018

Authors: Nahl Daniel, Nelson Marvin, Berkovich Rachel, Goodarzian Fariba, Lai Lillian

Keywords: FDG PET, Epilepsy, seizure

Massive ovarian enlargement (without underlying mass) is a rare finding in neonates. Ovarian enlargement has been associated with insulin-resistant states such as polycystic ovarian syndrome (PCOS) and rare congenital syndromes such as infants with leprechaunism. However, the extent, severity, and radiographic findings of ovarian growth in infants with syndromes of insulin resistance have not been fully described. We report a case of severe ovarian enlargement in an infant with congenital insulin resistance. A two-month-old born at 37 weeks via C-section with a history of intrauterine growth restriction was admitted for hyperglycemia consistent with neonatal diabetes and was subsequently diagnosed with insulin resistance syndrome (either leprechaunism or Rabson-Mendenhall syndrome) secondary to an <i>INSR</i> gene mutation. Insulin and proinsulin levels at 3 weeks of age were markedly elevated to 582.3 uIU/mL (2.0 – 19.6) and 674.3 pmol/L (≤ 18.8), respectively. An abdominal ultrasound (US) performed for abdominal distension demonstrated very enlarged ovaries containing sub-centimeter follicles. Ovarian volumes were 12.8 mL and 8.7 mL on the right and left, respectively. The mean ovarian volume for this age is 1.06 mL with a standard deviation (SD) of 0.96; this would place this patient's right and left ovaries 12.2 and 8.0 SD above the mean, respectively. CT performed at three months of age for evaluation of persistent fevers demonstrated further enlargement of the ovaries. Ovarian volumes were 106 mL and 60 mL on the right and left, which were 109 and 61 SD above the mean, respectively. A repeat US performed at four months of age showed decreasing ovarian volumes measuring 51 mL and 18 mL on the right and left, respectively (which were still 49 and 25 SD above the mean). We postulate that this case of massive ovarian enlargement in the setting of severe insulin resistance was likely due to an insulin-mediated gonadotropin-independent mechanism, as has been previously suggested in infants with leprechaunism (perhaps mediated through an intact homologous IGF-I receptor). The ovarian enlargement seen in post-pubertal females with PCOS may have a similar pathogenesis, with resultant granulosa cell proliferation with antral follicles. Ovarian cysts have also been seen in non-insulin-resistant hyperinsulinemic infants of diabetic mothers, suggesting that high circulating serum insulin may act in the trophic manner typical of gonadotropic hormones. Read More

Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020

Authors: Mikhchi Amir, Ryabets-lienhard Anna, Cheung Clement, Geffner Mitchell, Lai Lillian

Keywords: Ovarian Enlargement, Insulin-resistance

The pediatric thymus is a constant but confusing, dynamic entity. The goal of this educational exhibit is to illustrate the range of appearances of the normal thymus and to identify key imaging features that can help pediatric radiologists differentiate normal thymic tissue from neoplastic conditions and other mimics. Read More

Meeting name: IPR 2016 Conjoint Meeting & Exhibition , 2016

Authors: Lai Lillian, Halabi Safwan, Yeom Kristen, Barth Richard, Seekins Jayne

Keywords: thymus, ectopic, thymic, rebound, hyperplasia