In Li-Fraumeni Syndrome (LFS), early metabolic alterations can precede the structural evidence of cancer. This creates an important opportunity for PET-CT to detect tumors earlier than conventional imaging alone. Our objective was to illustrate the predictive value of serial PET-CT for early tumor detection in Trp53 mutant mice, using a representative case study. Read More

Meeting name: IPR 2026 Congress , 2026

Authors: Abdi Farnoush, Kafri Ran, Malkin David, Moineddin Rahim, Makhdoum Raghad, Man Carina, Doria Andrea

Keywords: Li-Fraumeni, PET/CT, Cancer

This study explored whether background 18F-FDG uptake differs between pediatric sarcoma cases (patients who underwent PET-CT as part of their clinical evaluation, at diagnosis, or during treatment) and non-oncologic NF-1 controls, reflecting possible systemic metabolic changes in cases that might distinguish tissues in this group from corresponding tissues in controls. Read More

Meeting name: IPR 2026 Congress , 2026

Authors: Makhdoum Raghad, Doria Andrea, Jenabihaghparast Elnaz, Lambert Liam, Hayden Reiltin, Abdi Fatemeh, Malkin David, Kafri Ran, Amirabadi Afsaneh, Vali Reza

Keywords: PET CT