Showing 5 Abstracts.
To determine the spectrum of abnormalities associated with DICER1 syndrome. To review imaging studies performed in oncologic staging and surveillance. To delineate the screening protocol used in those with positive genetic testing. Read More
Meeting name: IPR 2016 Conjoint Meeting & Exhibition , 2016
Authors: Tijerin Bueno Marta, De La Puente Gregorio Alejandro, Martinez-rios Claudia, Malkin David, Greer Mary-louise
Keywords: DICER1, Pleuropulmonary blastoma, pineoblastoma, cystic nephroma
In Li-Fraumeni Syndrome (LFS), early metabolic alterations can precede the structural evidence of cancer. This creates an important opportunity for PET-CT to detect tumors earlier than conventional imaging alone. Our objective was to illustrate the predictive value of serial PET-CT for early tumor detection in Trp53 mutant mice, using a representative case study. Read More
Meeting name: IPR 2026 Congress , 2026
Authors: Abdi Farnoush, Kafri Ran, Malkin David, Moineddin Rahim, Makhdoum Raghad, Man Carina, Doria Andrea
Keywords: Li-Fraumeni, PET/CT, Cancer
Magnetic resonance imaging (MRI) has become an increasingly valuable modality for evaluating pediatric chest pathologies beyond cardiac disease. Its diagnostic spectrum now extends to mediastinal, pulmonary, pleural, and chest wall abnormalities. Although traditionally limited by long acquisition times, motion artefacts, and the challenges of lung parenchyma imaging, recent advances such as ultrashort echo time (UTE), and zero echo time (ZTE) sequences have markedly expanded its clinical utility. This educational poster highlights the applications of MRI across a broad range of pediatric thoracic conditions, including mediastinal masses, congenital lung malformations, pulmonary tumors, infections, inflammatory diseases, and chest wall abnormalities. The mediastinal pathologies are structured according to the standard compartmental classification - prevascular, visceral, and paravertebral - to facilitate a systematic and anatomical approach to interpretation. Drawing on our institutional experience of primary to quaternary referrals, we will present cases to: 1. Review key MRI techniques applicable to pediatric thoracic imaging, including diffusion-weighted and contrast-enhanced imaging, as well as motion-suppression strategies. 2. Demonstrate MRI findings for mediastinal, pulmonary and chest wall pathologies, focusing on lesion characterization and delineation of relationships to adjacent structures and provide pearls and pitfalls for confident interpretation. 3. Discuss the role of MRI in children, given their heightened tissue sensitivity and increased lifetime risk of radiation-induced malignancy. The advantage is even more significant in patients with cancer predisposition syndromes, in whom cumulative radiation exposure is a major concern. 4. Outline practical workflow aspects, including preparation techniques such as feed-and-sleep imaging and child-life involvement, as well as safety considerations for repeated or contrast-enhanced studies. 5. Compare MRI with CT and radiography, underscoring its diagnostic strengths, limitations, and complementary role in specific clinical scenarios. 6. Provide a structured overview and practical framework to support the use of chest MRI in pediatric imaging. This educational overview aims to familiarize radiologists with MRI’s current and evolving role in pediatric thoracic imaging, highlight achievable image quality and diagnostic confidence, and encourage broader clinical adoption of radiation-free chest MRI in children. Read More
Meeting name: IPR 2026 Congress , 2026
Authors: Schmidt Magdalena, Manson David, Zanette Brandon, Chiu Priscilla, Malkin David, Villani Anita, Greer Mary-louise
Keywords: Chest MRI, Lung Imaging, Mediastinum
Whole-body (WB) magnetic resonance (MR) imaging in children is of special interest because it is radiation free and can be used to evaluate systemic conditions, exploiting the advantage of the superior soft-tissue contrast provided by MR imaging. An important clinical application of whole-body MR imaging in children is its use for screening of oncologic conditions, tumor characterization, and staging. However, the list of non-oncologic applications of WB MRI has recently expanded to include the evaluation of numerous multisystemic conditions. This is a pictorial review of different oncologic applications of WB MRI including cancer predisposition syndromes, solid neoplasias and lymphomas, as well as of non-oncologic applications of WB MRI including chronic recurrent osteomyelitis (CRMO), enthesitis related arthritis (ERA), vascular malformations and benign tumors. In this review we discuss the advantages and challenges of conventional and functional MRI sequences including the use of diffusion weighted imaging (DWI), color-encoded DWI enhanced with iron supplement Ferumoxytol as blood pool contrast agent, as well as the advantages and disadvantages of the recently introduced WB positron emission tomography (PET)/MRI. Read More
Meeting name: IPR 2016 Conjoint Meeting & Exhibition , 2016
Authors: Martinez-rios Claudia, Malkin David, Vali Reza, Shammas Amer, Tijerin Bueno Marta, Greer Mary-louise, Doria Andrea
This study explored whether background 18F-FDG uptake differs between pediatric sarcoma cases (patients who underwent PET-CT as part of their clinical evaluation, at diagnosis, or during treatment) and non-oncologic NF-1 controls, reflecting possible systemic metabolic changes in cases that might distinguish tissues in this group from corresponding tissues in controls. Read More
Meeting name: IPR 2026 Congress , 2026
Authors: Makhdoum Raghad, Doria Andrea, Jenabihaghparast Elnaz, Lambert Liam, Hayden Reiltin, Abdi Fatemeh, Malkin David, Kafri Ran, Amirabadi Afsaneh, Vali Reza
Keywords: PET CT