Alzaher Asrar,  Busaeed Fajir,  Alsayegh Hassan

Final Pr. ID: Poster #: SCI-033

In the background of this limited data, this study aims to analyze and compare the size significance of right iliac fossa lymph nodes in pediatric patients in relation to metabolic activity on (18F-FDG PET/CT), scan in tertiary center managing oncological and non-oncological cases. Read More

Authors:  Alzaher Asrar , Busaeed Fajir , Alsayegh Hassan

Keywords:  Lymph node size, PET/CT, CT

Aboagye Rosemond,  Bajno Lydia,  Nadel Helen,  Potts James,  Bray Heather

Final Pr. ID: Poster #: SCI-063

Purpose: ¹⁸F-FDG Positron Emission Tomography (PET-CT) has been shown to be superior to other imaging modalities in assessment of soft tissue involvement with Langerhans Cell Histiocytosis (LCH) and is now commonly included in the staging workup of LCH. Our purpose is to analyze the utility of skeletal survey in addition to PET-CT scan for detecting bone lesions in children with LCH and to evaluate if skeletal survey can be eliminated from the staging workup of LCH in order to reduce radiation exposure. Read More

Authors:  Aboagye Rosemond , Bajno Lydia , Nadel Helen , Potts James , Bray Heather

Keywords:  Langerhans Cell Histiocytosis, PET-CT, Skeletal Survey

Kim Joseph,  Shukla Neal,  Hammer Matthew,  Lozano Richard,  Hajibeygi Ramtin,  Tu Long,  Rao Balaji

Final Pr. ID: Poster #: SCI-024

History:
A 14-year-old female was brought to the emergency department following a self-harm incident. During her assessment, she was found to have elevated blood pressures and a prolonged QTc interval. She reported frequent episodes of palpitations and dizziness over the past year, often occurring immediately after urination.

Findings:
Initial ultrasound showed unremarkable kidneys and normal hemodynamics in the renal vessels. However, a heterogeneously echogenic mass with increased vascularity on color Doppler was visualized in the left bladder wall. MRI confirmed that the mass originated from the bladder base and extended through the left bladder wall, showing avid contrast enhancement and restricted diffusion. Gallium-68 Dotatate PET/CT demonstrated intense radiotracer uptake in the bladder mass, left pelvic sidewall, and left internal iliac lymph nodes.

The patient underwent chemotherapy and partial cystectomy. Pathology revealed neuroendocrine and nested features with infiltration into the smooth muscle bundles consistent with the muscularis propria of the bladder. Tumor cells tested positive for chromogranin and synaptophysin immunostains, while pan-cytokeratin (AE1/AE3) was negative. Genetic testing identified the R242H variant in the SDHB gene.

Discussion:
Bladder paragangliomas are rare neuroendocrine tumors arising from the sympathetic paraganglia present in the bladder wall. They represent 6% of extra-adrenal paragangliomas and 0.05% of all bladder tumors. Typical symptoms include hypertension, hematuria, and catecholamine-associated symptoms like headaches and palpitations during micturition. Up to 63% of bladder paraganglioma patients have a germline mutation, most commonly in the SDHB subunit gene, increasing their risk of developing pheochromocytomas and additional paragangliomas. Therefore, lifelong biochemical and imaging screening from skull base to pelvis are recommended.

Conclusion:
Bladder paragangliomas are a rare variant of extra-adrenal pheochromocytomas. MRI plays an important role in the pretreatment diagnosis of bladder paraganglioma. Gallium-68 Dotatate PET/CT is highly specific and can help diagnose metastatic spread. Lifelong follow-up is recommended due to the risk of recurrence and metastasis, and the potential for developing additional paragangliomas or pheochromocytomas. Read More

Authors:  Kim Joseph , Shukla Neal , Hammer Matthew , Lozano Richard , Hajibeygi Ramtin , Tu Long , Rao Balaji

Keywords:  Bladder, PET/CT, Nuclear Medicine

Binkovitz Larry,  Sutton Samuel

Final Pr. ID: Poster #: CR-032

To present the first PET/CT and PET/MRI imaging findings of acase of multiple myeloma, MM, in a pediatric patient. Read More

Authors:  Binkovitz Larry , Sutton Samuel

Keywords:  Plasmacytoma, PET/CT, PET/MR

Kato Kambrie,  Mackenzie John,  Phelps Andrew,  Courtier Jesse,  Behr Spencer,  Zapala Matthew

Final Pr. ID: Poster #: SCI-033

Determine the incidence of occult malignancy detected by ¹⁸F-FDG PET-CT and whole body (WB) MRI in children. Read More

Authors:  Kato Kambrie , Mackenzie John , Phelps Andrew , Courtier Jesse , Behr Spencer , Zapala Matthew

Keywords:  whole body MRI, PET CT, paraneoplastic syndrome