There is limited understanding and utilization of dynamic contrast enhancement MRI of marrow, periosteum and cartilage for diagnosis of musculoskeletal (MSK) disease in children. This is partly due to limited availability of pediatric disease models of marrow inflammation, infection, infiltration, or involvement by tumor. Herein we explore signal intensity time curves of relevant MSK targets using a 3D Golden-angle RAdial Sparse Parallel (GRASP) MRI technique. GRASP is an accelerated, free-breathing dynamic acquisition that has been shown to reduce the need for sedation. We aim to establish a baseline for normal enhancement characteristics of marrow, cartilage, synovium and periosteum of the growing skeleton in a sheep model as a precursor to translation to children. Read More

Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019

Authors: Rees Mitch, Milks Kathryn, Krishnamurthy Ramkumar, Krishnamurthy Rajesh, Hu Houchun

Keywords: radial MRI, dynamic contrast enhancement, musculoskeletal