Purpose or Case Report: Lipoblastoma is a benign, rare pediatric mesenchymal tumor that develops in a myriad of anatomic locations. The imaging appearance of lipoblastoma sometimes overlaps with other tumors. Familiarity with lipoblastoma and a knowledge of benign and malignant tumors with similar imaging features will benefit practicing Radiologists, Pediatricians, and Surgeons. Our exhibit aims to expand awareness of lipoblastoma by providing a comprehensive pictorial review of cases showcasing representative MRI, CT, sonographic, and radiographic images. Suggestive imaging features of lipoblastoma that distinguish them from other fat-containing lesions will be highlighted and an emphasis on the discussion of lipoblastoma within the spectrum of pediatric lipomatous lesions will be detailed.
Methods & Materials: A diagnostic imaging approach to lipoblastoma utilizing high-quality representative images will be presented. Histopathologically-proven cases of lipoblastoma from 2 large children’s hospitals will be presented encompassing an array of locations and imaging modalities.

1. Imaging features of lipoblastoma are reviewed including masses with fat as the sole component, masses with mixed fat and soft tissue, and masses with predominantly soft tissue and minimal or no visible fat (Figures 1, 2).
2. Highlight other benign and malignant fat-containing lesions in children where imaging features may overlap with lipoblastoma such as atypical lipoma, liposarcoma, hibernoma, and teratoma with extensive fatty elements.
3. Review complications of lipoblastoma such as compression of adjacent critical structures and neurovascular involvement (Figure 3).
Results: Lipoblastomas present in young children in a variety of locations and most often demonstrates predominantly fatty characteristics however may demonstrate septae, enhancing components, and solid components depending on its stage of differentiation. Lipoblastoma may present in a focal form or diffuse infiltrative form (lipoblastomatosis). Surgical excision with histopathologic and genetic confirmation is required for lipoblastoma, given the overlapping imaging characteristics with other soft tissue lesions.
Conclusions: It is prudent for pediatric radiologists to recognize the various imaging presentations of lipoblastoma and to consider a differential diagnosis that includes the full spectrum of lipomatous lesions, including malignant lesions. This approach will increase diagnostic recognition of lipoblastoma and improve diagnostic confidence when this entity is encountered.