Purpose or Case Report: Small Round Blue Cell Tumors comprises a group of highly aggressive malignant tumors with overlapping morphological pattern and immunophenotypic characteristics. They represent a challenge for surgical pathologists, as they require a broad panel of antibodies, mostly not used in the routine work of most pathology laboratories. In the required multidisciplinary approach, radiologists play a vital role in narrowing the diagnosis. The aim of the presentation is to describe the imaging appearance of several Small Round Blue Cell Tumors, mainly in Magnetic Resonance (MR). Teaching cases from our Radiology Department will be used to illustrate the following: a) Ewing sarcoma; b) Peripheral primitive neuroectodermal tumor; c) Neuroblastoma; d) Wilms tumor; e) Hepatoblastoma; f) Embryonal Rhabdomyosarcoma; g) Medulloblastoma; h) Pineoblastoma; i) Retinoblastoma; j) Central Nervous System primitive neuroectodermal tumor; k) Neuroepithelioma; l) Desmoplastic small round cell tumor.
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