Daneff Monica,  Casalis Claudia,  Bruno Claudio,  Bruno Didier

Final Pr. ID: Poster #: SCI-070

Radiographic bone age determination is part of the routine evaluation of suspected growth disorders. Simplicity and low cost are its major advantages but ionizing radiation should be taken into consideration. Conventional ultrasonography (US) has proven effective to identify ossification centers of the hand and wrist between 0 and 24 months of age. It may become an innocuous follow-up tool for patients with growth disorders. We aimed to asses the chronological US emergence of the ossification centers of the hand and wrist in healthy infants between 2 and 4 years of age. Read More

Authors:  Daneff Monica , Casalis Claudia , Bruno Claudio , Bruno Didier

Keywords:  Bone age, ultrasound, Growth, ULTRASOUND

Tokaria Rumana,  Jaramillo Diego

Final Pr. ID: Poster #: SCI-023

It is estimated that the ratio between the femoral and tibial growths is 0.94/0.67 (1.4), but the accuracy of the data used to obtain it is limited. We aim to find a correlation between the rate of new bone growth in between each zebra line in the patients with Osteogenesis Imperfects (OI) who have received cyclic bisphosphonate (BP) therapy with each treatment cycle between the distal tibia and proximal femur. This will allow us to quantify the growth of the distal femur and proximal tibia with accuracy. Read More

Authors:  Tokaria Rumana , Jaramillo Diego

Keywords:  Osteogenesis Imperfecta, zebra lines, growth rate

Neelavalli Jaladhar,  Romero Roberto,  Hernandez-andrade Edgar,  Mody Swati,  Yadav Brijesh,  Kabrera Maria,  Jella Pavan,  Yeo Lami,  Haacke Ewart,  Hassan Sonia

Final Pr. ID: Poster #: SCI-051

Fetal intracranial volume is one of the most important parameters used in assessing normal fetal growth. Based on volumetric ultrasound (US), Virtual Organ Computer-Aided-anaLysis (VOCAL^TM) is a commonly used technique for such measurement. Magnetic resonance imaging (MRI) offers better soft tissue contrast for fetal brain imaging and is considered as one of the best tools for tissue volumetry, and as a standard for comparison. In this work we compare fetal intracranial volumes measured from MRI with those obtained from VOCAL^TM measurements in the same fetuses. Read More

Authors:  Neelavalli Jaladhar , Romero Roberto , Hernandez-andrade Edgar , Mody Swati , Yadav Brijesh , Kabrera Maria , Jella Pavan , Yeo Lami , Haacke Ewart , Hassan Sonia

Keywords:  correlation, volumetry, HASTE, VOCALTM, fetal growth

Arioz Habibi Hatice,  Alici Davutoglu Ebru,  Kandemirli Sedat Giray,  Aslan Mine,  Ozel Aysegul,  Kalyoncu Ucar Ayse,  Zeytun Pinar,  Madazli Riza,  Adaletli Ibrahim

Final Pr. ID: Poster #: SCI-031

The aim of this study was to investigate the value of placental shear wave velocity and differences of placental elasticity between intra-uterine growth restriction(IUGR) and normal pregnancies. Read More

Authors:  Arioz Habibi Hatice , Alici Davutoglu Ebru , Kandemirli Sedat Giray , Aslan Mine , Ozel Aysegul , Kalyoncu Ucar Ayse , Zeytun Pinar , Madazli Riza , Adaletli Ibrahim

Keywords:  Intrauterine growth restriction, placental elasticity, shear wave elastography

Santos Laura,  Jaramillo Diego,  Raya José,  Jambawalikar Sachin,  Nguyen Jie,  Mostoufi-moab Sogol

Final Pr. ID: Poster #: EDU-053

Diffusion tensor imaging (DTI) depicts the anisotropic motion of water molecules limited by tissue microstructure. Images of tractography provide qualitative information about complex tissue architecture, so that diffusion metrics reflect physeal activity.
DTI’s main clinical application is on brain white matter, but it can be used in any tissue in which there is organized tissue structure. Our research group has used tractography of the knee to study the structure of the physis and adjacent metaphysis and investigated the potential of DTI metrics as biomarkers predictive of skeletal growth. DTI parameters include tract count, tract length and tract volume and fractional anisotropy (FA). They can help distinguish between a normal and a dysfunctional physis, predict post-imaging growth and physeal closure, and possibly determine response to growth hormone treatment.
We will demonstrate the techniques for data acquisition, preprocessing, and analysis, and the basis for interpretation, based on our experience of performing DTI in over 900 knees. Each step has its own challenges for the standardization and optimization of DTI of the physis. The goal of this poster is to showcase our experience with the establishment of an efficient DTI pipeline. We will: 1) Discuss the impact of variation of DTI acquisition parameters (e.g. Time to Echo (TE), number of directions, b-value, voxel size…); 2) Describe programs for distortion correction and denoising , as well as the required post-processing software programs; 3) Discuss approaches to standardize the acquisition in the different anatomic areas and cross vendors; 4) Discuss the normal change of tractography data and physeal DTI metrics with age, sex and specific knee physis. We will show how DTI changes due to physeal dysfunction in different pathologies, such as growth hormone deficiency, trauma, arthritis, metabolic disorders and chemotherapy and radiation therapy. Finally, we will show how DTI can be used to predict height gain and final height compared to conventional bone age-based methods and standard growth charts, which are inaccurate and not generalizable to the current child/adolescent population. Read More

Authors:  Santos Laura , Jaramillo Diego , Raya José , Jambawalikar Sachin , Nguyen Jie , Mostoufi-moab Sogol

Keywords:  magnetic resonance imaging, growth plate, diffusion tensor imaging

Duong Phuong,  Mostoufi-moab Sogol,  Raya José,  Jaimes Camilo,  Delgado Jorge,  Jaramillo Diego

Final Pr. ID: Paper #: 057

To compare how 3D MRI measurements of physeal cartilage volume, and DTI measurements (tract volume and length) correlate with growth parameters and detect differences in growth between patients treated with cis-retinoic acid and controls.
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Authors:  Duong Phuong , Mostoufi-moab Sogol , Raya José , Jaimes Camilo , Delgado Jorge , Jaramillo Diego

Keywords:  magnetic resonance imaging, growth plate, short stature

Eksioglu Secil,  Nasto Luigi,  Miyanji Firoz,  Bray Heather

Final Pr. ID: Poster #: EDU-106

The major concern for scoliosis in young children is the potential for poor pulmonary function and increased mortality. Early arthrodesis as well as severe spinal deformities can lead to ‘thoracic insufficiency syndrome’ by arresting spine growth and altering the shape of the thorax which results in restrictive lung disease. Several growth friendly instrumentation systems have been introduced to allow for growth until the timing is appropriate for spinal fusion for early onset scoliosis. The terminolgy of ‘growth friendly procedures ‘ is used for those which guide the growth of the spine. Growth modulation procedures are different from growth friendly procedures in the sense that vertebral growth is modulated and not guided. We aim to familiarize the radiologist by reviewing the types of ‘growing spine’ procedures performed at our hospital with an emphasis on what the radiologists should know and include in their reports. Read More

Authors:  Eksioglu Secil , Nasto Luigi , Miyanji Firoz , Bray Heather

Keywords:  Scoliosis, Growing spine, Growth friendly

Mutasa Simukayi,  Liu Michael,  Duong Phuong,  Jambawalikar Sachin,  Mostoufi-moab Sogol,  Jaramillo Diego

Final Pr. ID: Paper #: 112

There is growing research in diffusion tensor imaging (DTI) for providing metrics and images of physeal structure and function, particularly in evaluating children with possible growth disorders. There is a need for a faster automated process to segment the diffusion data, however. We utilized a deep learning algorithm to automatically generate a region of interest (ROI) for use in fully automatic diffusion tensor tractography of cartilage columns in the distal femoral physis. Read More

Authors:  Mutasa Simukayi , Liu Michael , Duong Phuong , Jambawalikar Sachin , Mostoufi-moab Sogol , Jaramillo Diego

Keywords:  Deep learning, growth disorders, MRi