The long term effects of retained Gadolinium (Gd) are still under investigation, but may be of greater concern in pediatric patients. So far several factors that appear to influence Gd retention have been described. The chemical structure of the Gadolinium based contrast agents (GBCA) plays an important role, with linear agents showing greater deposition compared with macrocyclics, attributed to lower chelate affinity. Differences in GBCA washout may also play a role. In this study we investigated and quantified the presence of Gd bone deposits in pediatric patients receiving GBCA as well as in controls with no known exposure.
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Meeting name:
SPR 2020 Annual Meeting & Postgraduate Course
, 2020
Authors:
Stanescu Arta,
Maloney Ezekiel,
Shaw Dennis
Keywords:
Gadolinium,
Deposition,
bone