Increased fracture risk is a complication that occurs in the context of primary bone diseases such as osteogenesis imperfecta (OI). Despite being considered as the reference-standard, the use of dual-energy X-ray absorptiometry (DXA) to evaluate fragility fractures in OI has not been validated by prior systemic review. Identifying patients at greatest risk for bone fragility fractures and determining skeletal health markers that can monitor bone mass concerning response to bone-active treatments are important issues for clinicians. In this systematic review we assessed the clinical utility of DXA for evaluating osteoporotic bone in OI pediatric patients according to the U.S. Preventive Services Task Force guidelines. Read More

Meeting name: IPR 2016 Conjoint Meeting & Exhibition , 2016

Authors: Yacoub Daniel, Wang Kuan Chung, Shah Prakeshkumar, Moineddin Rahim, Doria Andrea

Keywords: Dual-energy X-ray absorptiometry (DXA), Osteogenesis imperfecta, Systematic review, Fracture, Clinimetric property

1. To determine short-term interval changes in T2 maps of knee cartilage of healthy boys before and after a 2-minute knee-squat exercise at 1.5T and 3T MRI; 2. To determine interval changes in T2 maps pre-exercise at 1.5T vs. 3T, and post-exercise at 1.5T vs. 3T; 3. To determine interval changes pre- and post-exercise among minimal-, moderate-, and high-activity subjects at 1.5T and 3T; and 4. To determine inter- and intra-reader reliability of 1.5 and 3T values. Read More

Meeting name: IPR 2016 Conjoint Meeting & Exhibition , 2016

Authors: Ahmed Humayun, Wang Kuan Chung, Sussman Marshall, Amirabadi Afsaneh, Moineddin Rahim, Wells Greg, Man Carina, Blanchette Victor, Doria Andrea

Keywords: Hemophilia, Arthropathy, Pediatrics, Inherited bleeding disorders, T2 mapping MRI