ARPKD causes diffuse microcysts in the kidney parenchyma, and cyst burden cannot be quantified by standard image segmentation methods. We sought to assess whether apparent diffusion coefficient (ADC) measured by DWI could serve as a non-invasive biomarker of ARPKD severity, with the hypothesis that ADC would be higher in cystic vs. non-cystic parenchyma due to higher extracellular water content. We examined whether ADC could distinguish healthy kidneys from those affected by ARPKD, and whether a threshold ADC value could be established to differentiate cystic vs. non-cystic parenchyma. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Heintzelman Briana, Khrichenko Dmitry, Carson Robert, Darge Kassa, Serai Suraj, Hartung Erum
ARPKD causes diffuse microcysts in the kidney parenchyma, and cyst burden cannot be quantified by standard image segmentation methods. We sought to assess whether apparent diffusion coefficient (ADC) measured by DWI could serve as a non-invasive biomarker of ARPKD severity, with the hypothesis that ADC would be higher in cystic vs. non-cystic parenchyma due to higher extracellular water content. We examined whether ADC could distinguish healthy kidneys from those affected by ARPKD, and whether a threshold ADC value could be established to differentiate cystic vs. non-cystic parenchyma. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Heintzelman Briana, Khrichenko Dmitry, Carson Robert, Darge Kassa, Serai Suraj, Hartung Erum
Assessment of fluid overload in hemodialysis patients is usually based on a patient’s ideal weight which presents a challenge, especially in children due to normal growth and development. Noninvasive, validated sonographic fluid balance measurements could potentially guide fluid removal in children undergoing hemodialysis. We examine changes in IVC diameter and lung b-lines in children pre- and post- dialysis. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Mpoti Makhethe, Ehlayel Abdulla, Back Susan, Poznick Laura, Hartung Erum, Otero Hansel
Keywords: hemodialysis, ultrasound, fluid overload
Volume overload is linked to increased cardiovascular morbidity and mortality in children receiving hemodialysis (HD). Clinician assessment of volume status lacks accuracy and has substantial inter- and intra- observer variability. We investigated the use of ultrasound (US) skin thickness, and muscle elastography in pediatric HD patients. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Ehlayel Abdulla, Okunowo Oluwatimilehin, Dutt Mohini, Howarth Kathryn, Poznick Laura, Morgan Xenia, Back Susan, Hartung Erum, Otero Hansel
Keywords: Ultrasound, Dialysis, Volume Overload