Showing 10 Abstracts.
Synthetic magnetic resonance imaging (SyMRI) is a new imaging technique that permits generating multiple contrast-weighted images based on relaxivity measurements of tissue properties in a single acquisition using a multi-echo, multi-delay saturation recovery spin-echo sequence of approximately 6 minutes. Read More
Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019
Authors: Goncalves Fabricio, Serai Suraj, Alves Cesar Augusto, Teixeira Sara, Zuccoli Giulio
Keywords: Synthetic MRI, BRAIN, Quantitative MRI
ARPKD causes diffuse microcysts in the kidney parenchyma, and cyst burden cannot be quantified by standard image segmentation methods. We sought to assess whether apparent diffusion coefficient (ADC) measured by DWI could serve as a non-invasive biomarker of ARPKD severity, with the hypothesis that ADC would be higher in cystic vs. non-cystic parenchyma due to higher extracellular water content. We examined whether ADC could distinguish healthy kidneys from those affected by ARPKD, and whether a threshold ADC value could be established to differentiate cystic vs. non-cystic parenchyma. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Heintzelman Briana, Khrichenko Dmitry, Carson Robert, Darge Kassa, Serai Suraj, Hartung Erum
ARPKD causes diffuse microcysts in the kidney parenchyma, and cyst burden cannot be quantified by standard image segmentation methods. We sought to assess whether apparent diffusion coefficient (ADC) measured by DWI could serve as a non-invasive biomarker of ARPKD severity, with the hypothesis that ADC would be higher in cystic vs. non-cystic parenchyma due to higher extracellular water content. We examined whether ADC could distinguish healthy kidneys from those affected by ARPKD, and whether a threshold ADC value could be established to differentiate cystic vs. non-cystic parenchyma. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Heintzelman Briana, Khrichenko Dmitry, Carson Robert, Darge Kassa, Serai Suraj, Hartung Erum
To investigate magnetic resonance (MR) imaging features of sacroiliac joint infections in children with respect to age and with clinical correlation. Read More
Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019
Authors: Cohen Sara, Biko David, Kaplan Summer, Barrera Christian, Serai Suraj, Nguyen Jie
Keywords: sacroiliitis
Gaucher disease is an inherited metabolic disorder due deficiency of the lysosomal enzyme β-glucocerebrosidase that results in the accumulation of abnormal macrophages (“Gaucher cells”) within multiple organs, most conspicuously affecting the liver, spleen and bone marrow. As the diagnosis is increasingly made during childhood and young adulthood, pediatric radiologists should be familiar with imaging features of Gaucher disease and its complications. Visceromegaly consisting of hepatosplenomegaly is a hallmark of Gaucher disease and uniformly present in cohorts of pediatric patients. In addition, bone marrow involvement with ‘Erlenmeyer flasks’ have been long recognized as part of this disease, although the classic radiographic finding is not present until adulthood. Marrow involvement confers significant morbidity for these patients with pain, bone infarcts and pathologic fracture. Traditionally, imaging of disease severity has been based on hepatic and splenic visceral organ enlargement and/or qualitative assessment of bone marrow involvement. However, advances in the understanding of Gaucher disease and observations of elevated ferritin levels and increased risk of hepatic fibrosis emphasize the importance of more comprehensive assessment of liver involvement beyond simple enlargement. Moreover, quantitative MRI assessment of bone fat-fractions also may have a role in assessing marrow involvement. These methods of disease assessment are important in addressing management decisions regarding enzyme replacement and substrate reduction therapy. Read More
Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019
Authors: Degnan Andrew, Serai Suraj, Ho-fung Victor, Barrera Christian, Wang Dah-jyuu, Ahrens-nicklas Rebecca, Ficicioglu Can
Keywords: Gaucher disease, bone marrow, hepatic involvement
Ultra-Short Echo Time (UTE) imaging, characterized by acquisition schemes with Echo Times (TE) of < 1 msec, have enabled new applications of pediatric musculoskeletal (MSK) MRI including cortical bone, tendons and ligaments. The protons in the bone collagen matrix have an effective T2* on the order of 20 – 80 µsec. The UTE sequence consists of a 40 µs long non-selective RF pulse followed by transmit/receive switch time and a 100% asymmetric data, i.e. free induction decay, acquisition from the center to the surface of a sphere. In order to achieve the shortest possible TE, data acquisition starts already during ramp-up time of the readout gradient. The aim of our study was to assess the feasibility and compare two UTE sequences, a prototype 3D UTE with radial koosh-ball acquisition and clinically available pointwise encoding time reduction with radial acquisition (PETRA), in pediatric patients referred for clinical MSK studies. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Serai Suraj, Carson Robert, Venkatesh Tanvi, Kollasch Peter, Liu Ke Cheng, Rajapakse Chamith, Nguyen Jie
Keywords: UTE
Nephron sparing surgery for renal masses is indicated for pediatric patients with bilateral renal masses and masses associated with syndromic conditions predisposed to recurrence. However, there is a paucity of literature on MRI-based biomarkers in patients undergoing partial nephrectomy. Relating these imaging biomarkers to patient outcomes might inform surgical decision making and patient counseling. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: El-ali Alexander, Mittal Sameer, Boyer Kathleen, Long Christopher, States Lisa, Back Susan, Khrichenko Dmitry, Serai Suraj
Keywords: Imaging Biomarkers, MRI, Renal Tumor
Anatomic changes during bone growth and skeletal maturation are under-studied and incompletely understood, partially attributed to the sparing use of ionizing radiation in children. Recently, a clinically-feasible UTE (ultra-short echo time) MRI technique has emerged, enabling the direct visualization of bone. Although validated in adults, its spatial resolution and reproducibility have not been fully investigated in children. Therefore, the purpose of this study is 1) to determine the feasibility of UTE MRI to quantify changes in vertebral porosity and disc hydration along the thoracolumbar spine and 2) to investigate inter-rater reproducibility. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Nguyen Jie, Hong Shijie, Nguyen Michael, Venkatesh Tanvi, Serai Suraj, Carson Robert, Barrera Christian, Cahill Patrick, Rajapakse Chamith
Keywords: quantitative MRI, bone, spine
MR elastography (MRE) is increasingly being used to non-invasively assess diffuse liver disease in children. However, there are limited normal liver stiffness data for MRE in children. The purpose of this study was to determine normal liver stiffness measured by MRE for children and assess for associations with demographic factors, MRI field strength and MRI vendor. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Trout Andrew, Zhang Bin, Dillman Jonathan, Anupindi Sudha, Gee Michael, Khanna Geetika, Xanthakos Stavra, Baikpour Masoud, Calle-toro Juan, Ozturk Arinc, Serai Suraj
Keywords: Elastography, MR, Liver
Fontan–associated liver disease (FALD) is associated with increased risk of liver cirrhosis and hepatocellular carcinoma. Liver biopsy is the current gold standard investigation for diagnosing liver fibrosis. Magnetic Resonance Elastography (MRE) is a non-invasive procedure assessing liver stiffness. To date, only limited published studies are available describing the correlation of MRE and biopsy in Fontan-associated pediatric patients. Further, longitudinal changes in MRE require an increase in hepatic stiffness of >22% to indicate true change in stiffness (95% CI). The purpose of this study is to determine the clinical implication of MRE in FALD. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Tsitsiou Yvonne, Rychik Jack, Biko David, Cahill Anne Marie, Serai Suraj, Durand Rachelle, Golberg David, Glatz Andrew, Rand Elizabeth, Wilkins Benjamin, Witschey Walter, Dodds Kathryn, Russo Pierre
Keywords: MR Elastography, Fontan, Liver Biopsy