Showing 11 Abstracts.
CHOP-fMRU (www.chop-fmru.com), a functional MR Urography (fMRU) post processing tool, was released publicly in 2010. Since its release, I have gotten many questions about various aspects of fMRU post processing. This experience has aided in the development of pMRI (www.parametricmri.com), the successor to CHOP-fMRU. The aim of this electronic poster is to teach fMRU post processing using pMRI through several anonymized examples as well as address common questions that arise. An fMRU report is automatically generated and discussed at the end of each analysis. A comparison between fMRU and MAG3 with examples is included to better understand fMRU functional parameters. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Khrichenko Dmitry
Keywords: MRU, Post Processing, Urogram
Diffusion weighted imaging (DWI) is used in many diverse clinical and research applications including evaluation of stroke, avascular necrosis, renal tumor classification and others. Standardizing the apparent diffusion coefficient (ADC) value across different studies and institutions has proven difficult due to change in equipment and protocols used. The aim of this electronic poster is to explain this inconsistency in ADC estimation using the pMRI (www.parametricmri.com) software package. Variability in ADC due to b-value selection, low SNR, decay model choice, and theoretical perfusion effects is explained and demonstrated by image analysis of anonymized cases. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Khrichenko Dmitry
Keywords: DWI, ADC, Post Processing
Magnetic Resonance Imaging (MRI) R2 and R2* relaxometry has been shown to accurately quantify liver iron content (LIC) without the need for invasive biopsy. However, different post processing techniques and different calibration curves can lead to variability in the measured iron content. A detailed demonstration using the pMRI software package (www.parametricmri.com) of how to analyze R2 and R2* MRI relaxometry images to estimate LIC is presented. Linear monoexpoential, non-linear monoexpoential, biexponential and truncation models are used, compared and discussed. A selection of established LIC vs R2* calibration curves are compared in real time. Anonymized example cases of varying levels of iron overload are used to demonstrate segmentation techniques including region growing and semi-automatic vessel exclusion. After each analysis, a detailed LIC report is automatically generated and explained. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Khrichenko Dmitry
Keywords: LIC, Post Processing, MRI
This study will normalize contrast enhancement curves for three GBCAs in fMRU and use it to assess for differences in renal enhancement characteristics of different GBCAs used in pediatric fMRU. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Bhatia Aashim, Khrichenko Dmitry, Otero Hansel
Keywords: Functional, Gadolinium, Urography
Radiogenomics refers to the correlation of imaging and genomic data of tumors in cancer patients. This study attempts to make correlations between biomarkers in NGS Comprehensive Solid Tumor Panel reports and MRI imaging findings in neuroblastoma patients. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Holroyd Alexandria, Khrichenko Dmitry, States Lisa
Keywords: Neuroblastoma, Radiogenomics
Ultrasound (US) is a powerful imaging tool in the evaluation of neonates with suspected hypoxic-ischemic encephalopathy (HIE). US evaluation of the neonatal brain has been mainly performed qualitatively, comparing intracranial structures with different echotextures. Qualitative US analysis of the neonatal HIE brain may vary according to technical variations, the severity of the injury and the presence of coexistent complications. Quantitative analysis of the neonatal brain echotexture has been seldom attempted. Our aim was to compare the echotextures of specific brain regions between HIE patients and controls. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Goncalves Fabricio, Khrichenko Dmitry, Zheng Qiang, Hwang Misun
Keywords: Ultrasound, Hypoxic-ischemic encephalopathy
ARPKD causes diffuse microcysts in the kidney parenchyma, and cyst burden cannot be quantified by standard image segmentation methods. We sought to assess whether apparent diffusion coefficient (ADC) measured by DWI could serve as a non-invasive biomarker of ARPKD severity, with the hypothesis that ADC would be higher in cystic vs. non-cystic parenchyma due to higher extracellular water content. We examined whether ADC could distinguish healthy kidneys from those affected by ARPKD, and whether a threshold ADC value could be established to differentiate cystic vs. non-cystic parenchyma. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Heintzelman Briana, Khrichenko Dmitry, Carson Robert, Darge Kassa, Serai Suraj, Hartung Erum
ARPKD causes diffuse microcysts in the kidney parenchyma, and cyst burden cannot be quantified by standard image segmentation methods. We sought to assess whether apparent diffusion coefficient (ADC) measured by DWI could serve as a non-invasive biomarker of ARPKD severity, with the hypothesis that ADC would be higher in cystic vs. non-cystic parenchyma due to higher extracellular water content. We examined whether ADC could distinguish healthy kidneys from those affected by ARPKD, and whether a threshold ADC value could be established to differentiate cystic vs. non-cystic parenchyma. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Heintzelman Briana, Khrichenko Dmitry, Carson Robert, Darge Kassa, Serai Suraj, Hartung Erum
Calyceal diverticula (CD) are rare lesions which are difficult to differentiate from renal cysts. Cross sectional examination with excretory imaging facilitates diagnosis in a noninvasive fashion. Functional MR urography (fMRU) provides comprehensive morphological, functional and excretory assessment of the kidney with CD. We aim to describe the findings of CD in fMRU. Read More
Meeting name: IPR 2016 Conjoint Meeting & Exhibition , 2016
Authors: Haroyan Harutyun, Ntoulia Aikaterini, Khrichenko Dmitry, Bellah Richard, Long Christopher, Darge Kassa
Keywords: Diverticulum, diverticula, MRU, MR urogram, Calyceal
Accurate preoperative imaging diagnosis of supratentorial pediatric intraventricular tumors is not always straightforward. Conventional MRI features such as T1- and T2-weighted signal and contrast enhancement may overlap among various choroid plexus tumors and embryonal tumors. This study aimed to perform apparent diffusion coefficient (ADC) histogram analysis, assessing various metrics in different intraventricular for histological classification. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Goncalves Fabricio, Khrichenko Dmitry, Martin-saavedra Juan, Alves Cesar Augusto, Teixeira Sara, Andronikou Savvas, Vossough Arastoo
Keywords: Intranventricular tumors, ADC, Diffusion
Nephron sparing surgery for renal masses is indicated for pediatric patients with bilateral renal masses and masses associated with syndromic conditions predisposed to recurrence. However, there is a paucity of literature on MRI-based biomarkers in patients undergoing partial nephrectomy. Relating these imaging biomarkers to patient outcomes might inform surgical decision making and patient counseling. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: El-ali Alexander, Mittal Sameer, Boyer Kathleen, Long Christopher, States Lisa, Back Susan, Khrichenko Dmitry, Serai Suraj
Keywords: Imaging Biomarkers, MRI, Renal Tumor