Showing 6 Abstracts.
Many diseases in pediatrics are relatively uncommon and imaging of these diseases is difficult to study due to small patient numbers at a single site. This limits the ability of single institutions to adequately power a study. Thus, there is a pressing need for a multi-site structure to combine data for rare diseases to appropriately power outcome studies. Our goal is to create an infrastructure to support pooling of imaging and clinical data across institutions to facilitate multi-institutional studies. Read More
Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019
Authors: Payne Erin, Martin-saavedra Juan, Victoria Teresa, Robinson Amie, Fickenscher Kristin, Chan Sherwin
Keywords: Registry, Multi-Institutional, imaging trials
Accurate preoperative imaging diagnosis of supratentorial pediatric intraventricular tumors is not always straightforward. Conventional MRI features such as T1- and T2-weighted signal and contrast enhancement may overlap among various choroid plexus tumors and embryonal tumors. This study aimed to perform apparent diffusion coefficient (ADC) histogram analysis, assessing various metrics in different intraventricular for histological classification. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Goncalves Fabricio, Khrichenko Dmitry, Martin-saavedra Juan, Alves Cesar Augusto, Teixeira Sara, Andronikou Savvas, Vossough Arastoo
Keywords: Intranventricular tumors, ADC, Diffusion
Postmortem imaging is increasingly used following stillbirths and neonatal death. Estimating time of death has legal, biological, and ethical implications. This study aims to investigate feasibility of prenatal MRI in estimating time of death in intra-uterine fetal demise (IUFD). Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Teixeira Sara, Alves Cesar Augusto, Martin-saavedra Juan, Goncalves Fabricio, Zarnow Deborah, Feygin Tamara, Andronikou Savvas
Primary mitochondrial disorders (PMD) in newborns can be misdiagnosed as hypoxic-ischemic encephalopathy (HIE), clinically and radiologically. The purpose of this study is to describe the frequency and patterns of brain MRI findings in children with PMD diagnosed during the neonatal period. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Alves Cesar Augusto, Teixeira Sara, Martin-saavedra Juan, Goncalves Fabricio, Goldstein Amy, Andronikou Savvas, Ganetzky Rebecca, Vossough Arastoo
Keywords: Newborn, mitochondrial disorders, Mitochondrial
Proton MRS (1H-MRS) is a technique to non-invasively study brain metabolites in vivo. 1H-MRS has been shown to detect abnormal brain accumulation of lactate in primary mitochondrial disorders (PMDs). However, differences in lactate concentration among the different PMDs have not been explored. We aimed to explore differences in quantitative 1H-MRS derived metabolite concentrations, particularly of lactate, and their ratios, in PMDs. We analyzed quantitative 1H-MRS data of the brain in pediatric patients with different types of genetically confirmed PMDs to evaluate differences in metabolite concentration and ratios. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Goncalves Fabricio, Wang Dah-jyuu, Goldman-yassen Adam, Martin-saavedra Juan, Alves Cesar Augusto, Teixeira Sara, Andronikou Savvas, Vossough Arastoo
Keywords: MR Spectroscopy, Mitochondrial, LCModel
Assessment of fetal brain perfusion with contrast-enhanced ultrasound (CEUS) has not been performed <i>in vivo </i>in congenital diaphragmatic hernia (CDH). The development of the EXTra-uterine Environment for Neonatal Development allows investigation of CEUS and fetal brain perfusion parameters. The purpose of this study was to assess for aberrations in brain perfusion using CEUS in fetal lambs with CDH and correlate with cardiac output data. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Didier Ryne, Martin-saavedra Juan, Sridharan Anush, Larson Abby, Coons Barbara, Coleman Beverly, Davey Marcus, Hedrick Holly, Flake Alan
Keywords: Congenital Diaphragmatic Hernia, Brain Perfusion, Contrast Enhanced Ultrasound