Showing 6 Abstracts.
Neuroblastoma (NBL) is the most common extracranial solid malignancy of childhood. Biological features are known to affect disease severity. Status of amplification of the MYCN proto-oncogene is among several factors that affect the prognosis. CT texture analysis of tumor provides a step from qualitative to quantitative assessment, with the added bonus of use of routinely acquired images without the need for further tests. The aim of the study is to ascertain the ability to differentiate between MYCN-amplified and non MYCN-amplified neuroblastoma on pre-treatment CT images. The hypothesis is that lesion microenvironment and heterogeneity may differ significantly between MYCN-amplified and non MYCN-amplified tumor. Such differences may be exhibited in first-order texture analysis techniques that could detect more subtle differences in tumor heterogeneity by quantifying both pixel attenuation. This retrospective study objective is to explore the correlation between the first –order CT texture analysis (CTTA) and MYCN amplification status of neuroblastoma. Read More
Meeting name: SPR 2020 Annual Meeting & Postgraduate Course , 2020
Authors: Marie Eman, Oudjhane Kamaldine
Keywords: Neuroblastoma., CT texture., Radiomics
Although rare, fibular hemimelia or congenital fibular deficiency (CFD), is the most common congenital long bone deficiency, with an approximate incidence of 7.4- 20 per 1 million live births. The clinical presentation of CFD represents a broad spectrum of manifestations, ranging from mild fibular deficiency with limb length discrepancy to a significantly short limb with multiple associated foot, ankle and knee deformities. Traditional FH classification such as Achterman and Kalamchi described the amount of fibular deficiency, which is today known to be unrelated to length discrepancy and foot deformity. Current classifications are based on the associated deformities of the ankle and subtalar joint, as the foot deformity is the main prognostic factor. Treatment should be tailored for each patient to maximize the lower limb function - this involves predicting the limb length discrepancy and then coming up with a surgical plan to correct these in the fewest number of surgeries spread out as much as possible throughout the child’s growing years, so that by skeletal maturity the child has achieved equal leg length, a functional plantigrade foot, excellent alignment of the hip, knee and ankle and, as needed, a stable knee joint. Multimodal imaging provides detailed evaluation of the osteochondral and extraosseous malformations. In-utero identification can be accomplished with prenatal ultrasonography. After birth, radiographs often show striking bony anomalies. Detailed information regarding associated crucial cartilaginous, articular, soft tissue, and vascular abnormalities required for preoperative planning necessitates the use of magnetic resonance (MR) imaging. The purpose of this poster is to: 1) review the various types of osteochondral and extra-osseous abnormalities of CFD as depicted by different imaging modalities, 2) describe the limitations of each of these modalities, 3) outline the image-based classification of CFD, 4) describe the options for treatment, and 5) discuss the post-operative imaging evaluation of CFD. Read More
Meeting name: SPR 2019 Annual Meeting & Postgraduate Course , 2019
Authors: Marie Eman, Perez Manuela, Aquino Michael, Stimec Jennifer
Keywords: hemimelia, congenital fibular deficiency
Pediatric facial and scalp lesions are a common indication for imaging. Ultrasound is often the first imaging modality in the work-up of these lesions. While many soft-tissue lesions are nonspecific on ultrasound, there are several which have a characteristic sonographic appearance, including pseudotumors such as asymmetric buccal fat pads and fat necrosis, vascular lesions such as infantile hemangioma and venous malformations, scalp lesions such as cephalohematoma and subgaleal fluid collection and other lesions including dermoid cysts and pilomatricoma. Prompt recognition of these lesions can reduce unnecessary further investigations and improve timely diagnosis and management. The aim of this pictorial essay is to demonstrate the characteristic sonographic appearances of the most common pediatric facial and scalp lesions with computed tomography and magnetic resonance imaging correlation where appropriate to aid in narrowing the differential diagnosis and if warranted direct subspecialty referral. Read More
Meeting name: SPR 2024 Annual Meeting & Postgraduate Course , 2024
Authors: Gerrie Samantha, Marie Eman, Branson Helen, Navarro Oscar
Keywords: Scalp, Face, Ultrasound
Abnormal head shape is a common indication for imaging. While radiographs and ultrasound can play an important role, computed tomography is often the first imaging modality in the imaging work-up of abnormal head shape. It is important to understand the imaging appearance of normal sutures on each imaging modality and the normal progression of suture closure. The aim of this pictorial essay is to demonstrate the normal imaging appearance of the sutures on radiograph, ultrasound and computed tomography and to illustrate the features of the most common synostoses including single-suture craniosynostoses involving the metopic, sagittal and coronal sutures, and multi-suture craniosynostosis including Apert’s syndrome, Crouzon’s syndrome and Pfeiffer syndrome. In particular, we discuss the imaging work-up of multi-suture craniosynostosis including use of magnetic resonance imaging with an emphasis on pre- and post-operative imaging features and reporting tips. Read More
Meeting name: SPR 2024 Annual Meeting & Postgraduate Course , 2024
Authors: Gerrie Samantha, Marie Eman, Navarro Oscar, Branson Helen
Keywords: Craniosynostosis, Skull, Sutures
Learning objectives: 1.Review the main pediatric cardiomyopathy phenotypes. 2.Clarify the role of MRI across the care pathway. 3.Walk through the key MRI sequences we actually use in kids. 4.Recognize the essential imaging findings that help us differentiate among them. - Introduction: Pediatric cardiomyopathies are a rare heterogeneous group of myocardial diseases but are the first cause of heart transplantation in children. Causes are diverse—genetic mutations, coronary anomalies, infections, toxins, arrhythmias—and sorting out phenotypes can be tricky because adult criteria are often not applicable to kids and because many kids don’t tolerate long exams. - Imaging techniques: Echocardiography represents the first first-line modality but it is often complemented with CMR as it allows a radiation-free differentiation between different phenotypes with unique myocardial tissue characterization, playing a key role in diagnosis, risk stratification, and treatment assessment. - Key MRI sequences: Conventional cardiomyopathies protocols in children may use 1.5 or 3 Tesla field strengths and include the following sequences: Initial localizers. Cine imaging. Phase contrast. Parametric mapping. LGE. - Dilated Cardiomyopathy: Most common. Leading cause of heart transplant. Dilated chambers. Reduced systolic function. LGE: Patchy or longitudinal mid-wall, transmural, subepicardial, or diffuse subendocardial involvement. Presence of LGE indicates poor prognosis and increased risk of SCD. Native T1 mapping is suggested to be the strongest independent predictor of diffuse myocardial disease, allowing for the identification of patients at risk for adverse outcomes. - Hypertrophic Cardiomyopathy: 2nd most common. LV hypertrophy z-score >2.5 (no family history) or >2 (with family history/genetic test). LVOT obstruction and SAM. LGE: Independent risk factor for SCD. Differential diagnosis with athlete's heart. - Arrhythmogenic Cardiomyopathy: RV and/or LV dilatation and reduced EF. Wall motion abnormalities – most important finding in kids. Myocardial fibrosis. Fatty infiltration rare in children. - Restrictive Cardiomyopathy: Rarest CMP. Non-dilated biventricular failure and biatrial dilatation. Ddx: constrictive pericarditis. - Excessive trabeculation/NCCM: Non-compacted/Compacted myocardium ratio > 2.3 measured in diastole. In the absence of dilation or systolic dysfunction, can be considered a phenotypic trait not necessarily associated with CMP. Read More
Meeting name: SPR 2026 Annual Meeting , 2026
Authors: Navallas Maria, Zuccarino Flavio, Inarejos Clemente Emilio J, Marie Eman, Gerrie Samantha, Ladera Gonzalez Enrique, Barber De La Torre Ignasi
Keywords: Cardiomyopathy, Cardiac MRI
Thyroid cancer is the most prevalent endocrine malignancy in the pediatric population. Accurate diagnosis and staging of thyroid carcinoma demand a multimodality approach, including anatomic imaging with US, CT, and MRI, alongside functional or metabolic nuclear imaging. Novel imaging techniques such as US elastography, contrast-enhanced US (CEUS), superb microvascular imaging (SMI) and dual-source dual-energy thyroid CT have offered non-invasive tools to assess disease status. Furthermore, the emerging field of radiomics/radiogenomics and artificial intelligence is continuously growing, creating models to classify or predict disease behaviour. We provide a comprehensive overview of the essential imaging characteristics of pediatric thyroid carcinoma using conventional and novel imaging techniques. In addition, we illustrate the multimodality, multidisciplinary, and collaborative approach across pediatric radiology and nuclear medicine in pre-operative, post-operative and post-treatment imaging surveillance of cancer thyroid in children. Read More
Meeting name: SPR 2024 Annual Meeting & Postgraduate Course , 2024
Authors: Marie Eman, Navallas María, Gerrie Samantha, Olkh Juhi, Elghamudi Taha, Inarejos Clemente Emilio J, Navarro Oscar, Martinez-rios Claudia, Vali Reza