Arshad Wajiha, Igwe Chukwuemeka
Final Pr. ID: Poster #: EDU-050
Introduction:
Children with esophageal atresia, tracheoesophageal fistulas, and Hirschsprung disease often undergo early invasive surgeries to correct these anatomical malformations, ensuring adequate nutritional intake. However, over time, post-surgical anastomotic strictures can develop, leading to mechanical obstructions that impair swallowing or defecation. Traditional treatment for such strictures often involves re-do surgery, but this carries significant risks and recovery time. Our study explores the efficacy of a combined radiological and surgical approach to manage these strictures, aiming to reduce the need for further invasive surgeries.
Methods:
Between September 2022 and May 2023, we performed six procedures involving pediatric patients with symptomatic post-anastomotic strictures (five esophageal, one colorectal). Each patient presented with symptoms suggestive of mechanical obstruction, such as dysphagia or difficulty passing stool. Under general anesthesia, both a surgical consultant and an interventional radiologist performed the procedures. Initial endoscopy was followed by fluoroscopic guidance via a 0.018 wire introduced through the endoscope. Balloon dilatation, using a range of balloon sizes (10mm–27mm), was performed, and the outcomes were assessed via pre- and post-dilatation fluoroscopic imaging with water-soluble contrast. Repeat endoscopy was used to confirm the efficacy of the dilatation.
Results:
Of the six cases, five were successfully treated with balloon dilatation, with no immediate need for further invasive surgery. One case, although initially successful, required subsequent surgical intervention due to recurrent stricture. Post-procedural imaging and endoscopy confirmed patency in the remaining cases, with significant symptom improvement.
Discussion:
This study highlights the efficacy of a combined radiological and surgical approach in managing post-anastomotic strictures. The use of intraoperative endoscopic and fluoroscopic correlation allowed for precise dilatation, reducing the likelihood of recurrence and avoiding immediate re-do surgeries.
Conclusions:
A combined surgical and radiological approach to post-anastomotic strictures offers a less invasive, resource-efficient, and effective alternative to re-do surgery. The success rate of 83% demonstrates that balloon dilatation under fluoroscopic and endoscopic guidance is a valuable adjunct to conventional surgical management of these conditions.
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Authors: Arshad Wajiha , Igwe Chukwuemeka
Keywords: Interventional Fluoroscopic
Final Pr. ID: Poster #: EDU-068
Ischial tuberosity avulsion fractures, though not uncommon in adolescent athletes, are often overlooked or misdiagnosed. These fractures occur more frequently in males than females. Primary cause of this fracture type is usually a sudden eccentric load on the proximal hamstrings, typically seen during a kicking action in dance, football, or soccer. Due to the limited use of imaging in the evaluation of such injuries, these fractures often are misdiagnosed or underdiagnosed. Recent injuries warrant more conservative management, including rest and relative immobilization. In cases of late diagnosis, delayed healing, or persistent symptomatology, surgical intervention can be undertaken to restore normal anatomy, alleviate symptoms, and facilitate healing. Minimally invasive CT-guided percutaneous needle fenestration has been introduced for symptomatic delayed union ischial tuberosity fractures in adolescents. This percutaneous procedure involves the creation of multiple channels into the bone at the fracture site with an 18 gauge Chiba needle via image guided needle fenestration to enhance blood flow and promote healing of the target area. Following this, a tailored physical therapy program is implemented based on patient symptomatology, individual tissue healing rates, and the current literature related to proximal hamstring injuries. Outcomes to this minimally invasive approach have been promising including cases of complete pain relief, full functional recovery, and a return to sports without limitations.
Outline of Teaching Points:
Ischial tuberosity avulsion fractures are common in adolescent athletes, with a higher incidence in males, caused by sudden eccentric loads on proximal hamstrings during activities like dance, football, or soccer.
Due to limited imaging use, these fractures are often overlooked or misdiagnosed, leading to delayed healing or persistent symptoms.
Recent injuries may benefit from conservative management, involving rest and relative immobilization.
Surgical intervention becomes necessary for late diagnoses, delayed healing, or persistent symptoms to restore normal anatomy and alleviate symptoms.
Minimally invasive CT-guided percutaneous needle fenestration has shown promising outcomes, facilitating healing with complete pain relief and a return to sports without limitations.
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Authors: Malavia Mira , Rivard Douglas
Keywords: fracture, interventional radiology
Zhu Xiaowei, Whitaker Jayme, Shellikeri Sphoorti, Cahill Anne Marie
Final Pr. ID: Poster #: EDU-046
It is important for radiologists to recognize and discuss with patients and families the potential risks and clinical manifestations of high Peak Skin Dose. In children undergoing complex Interventional procedures accurate Peak Skin Dose estimates are complicated and time consuming despite reference point doses being available. The availability of the Dose Structure Report (SR) on modern fluoroscopic equipment allows such estimates to be timely and consistent. The process of creating a Peak Skin Dose estimate using a validated radiation data management system (RDMS), capable of collecting detailed acquisition data and modeling will be discussed. Read More
Authors: Zhu Xiaowei , Whitaker Jayme , Shellikeri Sphoorti , Cahill Anne Marie
Keywords: Peak Skin Dose Estimation, Interventional fluoroscopic, Radiation Data Management System
Dennison Jennifer, Nassar Arianna, Carter Scott, Kouri Brian
Final Pr. ID: Poster #: CR-032
Endoscopy-guided and image-guided gastrostomy tube placements have similar complication rates and range from 0.4-22.5% and 13-43% respectively. Of these, vascular injury occurs in approximately 1.4-2.5%. Understanding the imaging features, clinical presentations, and management of rare, severe, gastrostomy-related complications is crucial for early, accurate diagnosis and favorable outcomes. We present a rare case of exclusively intragastric hemorrhage from iatrogenic injury of an inferior epigastric artery following percutaneous gastrostomy tube placement. Case Report: A 4-year-old male patient with chronic constipation, failure to thrive, and developmental delay was admitted for abdominal distention and dysuria. A barium enema and biopsy confirmed short-segment Hirschsprung’s disease. He subsequently underwent diverting descending colostomy/mucous fistula creation, and laparoscopic gastrostomy tube placement. The following day he had a large-volume hematemesis. Hemoglobin was found to be 6.7 g/dL down from 12.4 g/dL preoperatively. Dark bloody output was noted in the gastrostomy tube trap. Emergent endoscopy demonstrated a massive amount of clot in the gastric lumen, and an obvious active bleed at the gastrostomy site with blood tracking along the gastrostomy tube stem. There was no evidence of hematoma or hemorrhage outside of the stomach by physical exam or endoscopy. A single bleeding vessel or pinpoint site amenable to endoscopic intervention was not identified. The patient proceeded to interventional radiology where initial angiography failed to identify an arterial source of bleeding involving the area suspected by endoscopy. The decision was made to empirically embolize the right gastroepiploic artery with gelfoam pledgets and slurry, as it was a low-risk intervention and the most likely source of arterial perfusion to the gastrostomy site. Further interrogation ultimately led, however, to identification of an active intragastric hemorrhage arising from a branch of the left inferior epigastric artery which was coil embolized. The patient recovered without incident and was discharged home 11 days later. Read More
Authors: Dennison Jennifer , Nassar Arianna , Carter Scott , Kouri Brian
Keywords: Arterial Embolization, Gastrostomy, Interventional Procedure
Shellikeri Sphoorti, Setser Randolph, Acord Michael, Srinivasan Abhay, Vatsky Seth, Escobar Fernando, Whitaker Jayme, Cahill Anne Marie
Final Pr. ID: Poster #: EDU-047
Percutaneous interventions are increasingly being performed under MR-guidance due to the absence of ionizing radiation, the ability to visualize target lesion and the capability to monitor real-time treatment effect. Here we outline our experience with developing an interventional MRI (iMRI) service at a pediatric institution. Read More
Authors: Shellikeri Sphoorti , Setser Randolph , Acord Michael , Srinivasan Abhay , Vatsky Seth , Escobar Fernando , Whitaker Jayme , Cahill Anne Marie
Keywords: Interventional MRI, MR-guided procedures
Ritchie David, Negrete Lindsey, Naheedy John
Final Pr. ID: Poster #: EDU-045
Trauma poses significant challenges to the pediatric emergency provider. From 1 to 14 years of age, traumatic injuries remain the leading cause of death for children in the United States. The majority of total mortality is attributable to motor vehicle collisions followed by bicycle accidents, falls, burns, and physical assaults. While the practice of interventional radiology (IR) in adults is undergoing considerable growth and expansion, so too are the techniques in their application to children.
We first review techniques that are more commonly encountered in pediatric IR trauma such as minimally invasive control of hemorrhage, percutaneous stenting, and arterial embolization. We then present cases that are less commonly encountered such as: hepatic laceration with pseudoaneurysm formation, pelvic fracture with CT-guided iliofixation, and humeral contusion with pseudoanuerysm formation of the anterior humeral circumflex artery. In all cases, the initial imaging performed in the emergency department will be highlighted throughout for each patient prior to showing any of the corresponding interventions.
After reviewing this exhibit, an attendee should be familiar with frequently encountered and less commonly encountered trauma in the pediatric IR setting. We hope the learner will gain comfort in the prompt recognition of acute traumatic pediatric imaging that may go on to subsequently require the intensivist’s attention.
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Authors: Ritchie David , Negrete Lindsey , Naheedy John
Keywords: Interventional, Trauma, Pseudoaneurysm
Tran Patrick, Kang Lisa, Gundeti Mohan, Long Jessica, Brown Colin
Final Pr. ID: Poster #: CR-029
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder resulting from mutations in genes encoding enzymes essential for adrenal hormone synthesis. It affects roughly 1 in 15,000 individuals and can present with ambiguous genitalia, salt-wasting, and virilization.
An 8-year-old girl with history of CAH and genitoplasty at age 2 presented with abdominal pain, brown perineal discharge, and fever (39°C). Labs were notable for leukocytosis (15 x 10^9/L).
Transabdominal ultrasound (TAUS) revealed a fluid-filled uterus and vagina with layering echoes. MRI confirmed a distended, fluid-filled uterus and vagina with layering debris. The ovaries were normal. Differential included imperforate or microperforate hymen, lower vaginal atresia, transverse vaginal septum, and vaginal outlet obstruction due to scarring.
On initial exam under anesthesia (EUA) findings of imperforate hymen were not present and placement of a speculum into an apparent narrowed vaginal introitus produced efflux of urine. Subsequent cystoscopy revealed that this channel led to the urinary bladder and a bladder catheter was placed.
Following discussion among pediatric gynecology, pediatric urology, and interventional radiology (IR), a joint EUA and drainage procedure was performed in the IR suite. A diminutive vaginal opening was identified and a cystoscope was advanced into the vagina under TAUS. The cystoscope was exchanged for a catheter and a fluoroscopic contrast vaginogram was performed, showing stricture of the vaginal introitus. Balloon stricturoplasty was performed, a Foley catheter was placed into the vagina, and the vaginal fluid was drained. The urinary bladder catheter was replaced and the bladder was decompressed.
After the procedure the patient's symptoms improved. Vaginal fluid culture grew E. faecalis. The patient was discharged with vaginal and bladder catheters in place and a 14-day antibiotic course.
Subsequent EUA by pediatric urology confirmed a single urogenital orifice with urethrovaginal communication, consistent with urogenital sinus anomaly and urethrovaginal fistula. Definitive surgery was deferred due to the patient’s age.
This case highlights the complexities of evaluating and treating children with urogenital anomalies and the importance of multidisciplinary collaboration in their management.
Final diagnosis: Vaginal outlet obstruction due to stricture managed with balloon dilation; urogenital sinus anomaly and urethrovaginal fistula secondary to CAH.
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Authors: Tran Patrick , Kang Lisa , Gundeti Mohan , Long Jessica , Brown Colin
Keywords: Interventional Radiology, Genitourinary, Urogenital Sinus
Final Pr. ID: Poster #: EDU-051
Introduction:
Gastrostomy insertion provides essential long-term nutritional support for patients due to neurological or congenital conditions. While common in both adults and children, pediatric patients present unique challenges requiring specialized techniques. This article highlights the differences between pediatric and adult gastrostomy procedures and explores how to optimize outcomes .
Anatomical Considerations:
Pediatric patients have smaller abdominal cavities, thinner abdominal walls, and smaller stomachs, increasing the risk of injury during gastrostomy. These factors necessitate smaller instruments and specialized techniques. The pliability of the pediatric abdominal wall makes securing the gastrostomy tube crucial to prevent dislodgement or leakage. Ensuring accurate tube placement is essential to avoid trauma and complications.
Physiological Differences:
Children have higher metabolic rates and rapid growth, affecting their nutritional needs and healing after surgery. Considerations include complications such as reflux or poor feed tolerance. Smaller stomach volume also requires careful tube size and placement.
Technique Modifications:
Percutaneous Endoscopic Gastrostomy (PEG): Adjusted for smaller anatomy.
Radiologically Inserted Gastrostomy (RIG): Ideal for children with complex surgical histories; guided placement reduces injury risk, though minimizing radiation exposure is vital.
Laparoscopic Gastrostomy: Used when direct visualization is needed, particularly for complex cases.
Radiological considerations include fluoroscopic visualization of the stomach bubble and liver ultrasound to assess organ positioning.
Postoperative Considerations:
Children are more prone to complications such as infection, leakage, and tube dislodgement. Educating caregivers on tube care and recognizing complications is critical to ensure proper nutrition and tube functionality.
Optimizing Outcomes:
A multidisciplinary approach involving pediatric surgeons, gastroenterologists, and radiologists is essential. Preoperative planning must address anatomical and medical complexities, while postoperative care should include ongoing monitoring and adjustments as the child grows.
Conclusion:
Pediatric gastrostomy requires adaptations of adult techniques to account for children’s anatomical and physiological differences. A multidisciplinary approach with careful planning and specialized care is vital for minimizing complications and ensuring successful outcomes.
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Authors: Arshad Wajiha
Keywords: Interventional Radiology
Tierradentro-garcia Luis, Martinez Mesha
Final Pr. ID: Poster #: EDU-063
Background:
Connective tissue disease can affect multiple systems in children. In the central nervous system, these entities can present as cerebrospinal fluid (CSF) disorders, such as CSF leaks, due to dysregulation of collagen and/or other extracellular matrix components. Most patients present with chronic, daily, unremitting headaches that usually improve when lying down. Imaging findings can show classic signs of intracranial hypotension, signs of idiopathic intracranial hypertension, or both. The latter, termed “mixed CSF pressure disorders”, a newer entity described in the literature, can present a diagnostic dilemma as patients can present with atypical symptoms in combination with a clinical history of hypermobility. Conventional CT myelography can confirm capacious thecal sacs, multiple CSF leaks, prominence of perimedullary veins, or multiple dural diverticula. The senior author, a pediatric neurointerventionalist, treated the presented cases.
Education goals:
1) To present common heritable (e.g. COL11A2, COL5A2, ADAMTS2, ZNF469, FBN1, FLNA, TNXB) connective tissue diseases that can manifest with CSF disorders in children.
2) To highlight the main findings on conventional CT myelography to detect CSF leaks.
3) To correlate CT myelography findings with brain and spinal MRI in children with CSF disorders.
4) To discuss the options for management from a neurointerventional perspective.
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Authors: Tierradentro-garcia Luis , Martinez Mesha
Keywords: CSF, Interventional
Metz Terrence, Richer Edward, Vellody Ranjith
Final Pr. ID: Poster #: EDU-094
To present nine classic pediatric diagnostic imaging cases and their subsequent interventional managements in order to emphasize the interventionalist's role in caring for the child and educate the pediatric radiologist to guide further care. Read More
Authors: Metz Terrence , Richer Edward , Vellody Ranjith
Keywords: Interventional, biopsy, drain, angiography
Kleedehn Mark, Witt Jessica, Laeseke Paul, Woods Michael, Monroe Eric
Final Pr. ID: Poster #: SCI-009
To evaluate patient and procedural variables for association with clinical outcomes in pediatric patients receiving IR drains. Read More
Authors: Kleedehn Mark , Witt Jessica , Laeseke Paul , Woods Michael , Monroe Eric
Keywords: Abscess, Interventional Radiology
Acord Michael, Termine Carl, Cahill Anne Marie, Escobar Fernando
Final Pr. ID: Poster #: SCI-037
To assess the rate of dislodgement of posteriorly tunneled central lines, over-the-shoulder, in children. Read More
Authors: Acord Michael , Termine Carl , Cahill Anne Marie , Escobar Fernando
Keywords: venous access, back, interventional radiology
Hampton Erica, Fuentealba Cargill Andrea, Trenbeath Zachary, Alazraki Adina, Stence Nicholas, Milla Sarah
Final Pr. ID: Poster #: EDU-076
Brain death, also known as death by neurologic criteria, (BD/DNC) is the permanent loss of total brain function in individuals who have sustained catastrophic brain injuries. Accounting for approximately 5% of pediatric deaths, BD/DNC remains a clinical diagnosis, which is often emotionally laden and not always straightforward. When results are equivocal or there exist limitations to the safe completion of the clinical assessment, clinicians rely on ancillary testing to make informed decisions. In October 2023, updated adult and pediatric BD/DNC consensus guidelines were published which reinforce differences in the recommendations for testing between the adult and pediatric populations. It is, therefore, crucial for Pediatric Radiologists to understand these guidelines and the critical role radiology plays in supporting this important diagnosis.
In this educational exhibit, we will review the recent consensus guidelines and clinical indications for the use of imaging in BD/DNC evaluation. We will provide a step-by-step guide which will include patient preparation, radionuclide or contrast administration, image acquisition, and image interpretation for the two validated methods of pediatric BD/DNC ancillary testing: Radionuclide Perfusion Scintigraphy and 4-Vessel Catheter Angiography.
Although 4 vessel catheter angiography is considered the gold standard in ancillary BD/DNC testing, as it is believed to be both 100% sensitive and 100% specific, radionuclide scintigraphy is the more widely used modality in the pediatric population, owing to the less invasive nature of the exam. Neither exam is without challenges related to limited availability and technical skill required yet are currently the only validated radiologic tools recommended for use in brain death diagnosis. Our exhibit will review multiple cases of evaluation for BD/DNC, accentuating imaging findings and pearls/pitfalls of acquisition and interpretation. Opportunities for investigation of other available imaging techniques will also be highlighted.
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Authors: Hampton Erica , Fuentealba Cargill Andrea , Trenbeath Zachary , Alazraki Adina , Stence Nicholas , Milla Sarah
Keywords: Nuclear Medicine, Interventional Radiology
Yen Christopher, Kukreja Kamlesh, Masand Prakash
Final Pr. ID: Poster #: CR-010
Female conjoined throraco-omphalopagus twins were delivered via cesarean section at 35 weeks 5 days gestational age to a 38-year-old mother who received standard prenatal care. After resuscitation, the twins were transferred to the neonatal ICU, where they remained for monitoring and growth as they were assessed for potential separation.
CT angiography was performed at 3-4 months of life using a staged approach. Selective IV and oral contrast administration was used over two visits to delineate shared and non-shared structures. Most significantly, there was a single shared liver with anomalous hepatic venous drainage. Twin A had three normal caliber hepatic veins draining into a normal IVC, but a large branch of the middle hepatic vein traversed midline into Twin B and received hepatic venous drainage from Twin B via numerous anomalous vessels. Twin B had a normal IVC but three diminutive hepatic veins, thought to be due to reduced venous drainage as a result of the anomalous shared vasculature.
After multidisciplinary discussion, interventional radiology was consulted for hepatic venogram and intervention as needed. The anomalous communicating vessels were identified on hepatic venogram via Twin A femoral approach. Occlusion of the anomalous branches was achieved with serial embolization of the primary draining vessel on the Twin A side using Amplatzer vascular plugs. Successful occlusion was confirmed on venography after the final embolization procedure.
Follow-up Doppler ultrasound exams confirmed improved hepatic venous outflow in Twin B, initially with reversal of flow in the anomalous veins back toward the IVC of Twin B, followed by nonvisualization of the anomalous veins on later exams. CT angiography later showed enlarged caliber of the native Twin B hepatic veins. Following the optimization of hepatic venous outflow, the multispecialty surgical team proceeded with separation. The twins were separated at 13 months of age without complication. In addition to restoring venous outflow to allow for a successful surgical outcome, it was noted that the Amplatzer devices were used as surgical landmarks during separation for identification of shared anatomy. Through careful planning and execution, diagnostic and interventional radiology techniques played a critical role in this successful outcome.
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Authors: Yen Christopher , Kukreja Kamlesh , Masand Prakash
Keywords: Conjoined twins, Interventional Radiology, CT Angiography
Final Pr. ID: Poster #: CR-002 (R)
To demonstrate the finding of a Femoral artery Pseudoaneurysm on a Left Lower extremity venous and arterial doppler ultrasound and under Interventional Radiology sonographically guided compression of the neck of the Pseudoaneurysm and guided injection of thrombin into the Pseudoaneurysm resulted in successful thrombosis of a Pseudoaneurysm. Follow up ultrasounds to document resolving of a Left Femoral artery Pseudoaneurysm in an infant. Read More
Authors: Patel Falguni
Keywords: Doppler Lower extremity Ultrasound, Pseudoaneurysm, Interventional procedure.
Shum Thomas, Cleveland Heather, Chau Alex, Ashton Daniel, Hernandez Alberto
Final Pr. ID: Poster #: SCI-038
Stenosis of the inferior vena cava or the hepatic veins is an underlying cause for hepatic compromise in liver transplant patients and in patients with inflammatory diseases of the liver, leading to considerable morbidity. CT-guided or ultrasound-guided minimally invasive vessel recanalization procedures can reverse liver failure in these patients by restoring vessel patency. However, it can be difficult to employ these techniques using traditional guidewire tips against fibrotic obstructions associated with vessels that have undergone repeated stenosis. Sharp recanalization offers an alternative strategy to gain access through these obstacles by utilizing needles or the sharp end of the guidewire tip to penetrate the vessel obstruction. This technique has been well-described and employed successfully in adult patients, but has not yet been reported in the pediatric setting. Read More
Authors: Shum Thomas , Cleveland Heather , Chau Alex , Ashton Daniel , Hernandez Alberto
Keywords: interventional
Hailu Tigist, Ginader Abigail, Bodo Nicole, Sze Alyssa, Corder William, Thompson Lynn, Escobar Fernando, Sze Raymond, Balmer Dorene
Final Pr. ID: Paper #: 144
Little is known about how families of children undergoing interventional radiology (IR) procedures experience their interactions with IR teams; therefore, we conducted a qualitative study to explore and learn from families experience with IR teams in order to educate pediatric IR staff and ultimately improve delivery of care. Read More
Authors: Hailu Tigist , Ginader Abigail , Bodo Nicole , Sze Alyssa , Corder William , Thompson Lynn , Escobar Fernando , Sze Raymond , Balmer Dorene
Keywords: Interventional Radiology, patient experience
Final Pr. ID: Poster #: EDU-001
Introduction:
Artificial intelligence (AI) is set to transform pediatric interventional radiology (PIR) by enhancing precision, improving diagnostics, and streamlining workflows. Given the complexities of smaller anatomy and higher risks in pediatric patients, AI's integration into imaging and procedural planning will significantly support growth and improve outcomes in the next decade. This abstract outlines key areas where AI will impact PIR.
Key Areas:
Enhanced Imaging and Diagnosis:
AI algorithms will enable faster and more accurate identification of anatomical structures and abnormalities in pediatric patients. Automated image processing can highlight critical features, assisting interventional radiologists in making informed decisions. This technology will provide detailed anatomical maps to guide minimally invasive interventions.
Procedure Optimization:
AI will enhance procedure planning and execution by predicting complications and recommending optimal techniques. AI-powered navigation systems integrated with real-time imaging will assist radiologists in navigating complex anatomical pathways, reducing procedure times and minimizing radiation exposure. Automated measurement tools will further personalize treatment.
Improved Decision-Making:
AI can analyze data from previous procedures to support decision-making, helping radiologists choose the best treatment based on predictive analytics. Machine learning models can identify trends and suggest personalized interventions, standardizing best practices and improving success rates in pediatric interventions.
Workflow Efficiency:
AI-driven automation will streamline tasks such as scheduling, imaging analysis, and report generation, allowing radiologists to focus more on patient care. By predicting resource needs and optimizing timing, AI will enhance workflow efficiency and facilitate multidisciplinary collaboration.
Education and Training:
AI will revolutionize education in pediatric interventional radiology. Virtual reality (VR) and AI-based simulation platforms will enable trainees to practice complex procedures in realistic environments, providing real-time feedback and personalized learning pathways.
Conclusion:
AI’s integration into pediatric interventional radiology will enhance imaging, optimize procedures, and streamline workflows. By leveraging AI’s capabilities, PIR can achieve greater precision, reduce risks, and improve outcomes for pediatric patients, driving growth and advancement in the field.
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Authors: Arshad Wajiha
Keywords: Interventional Radiology
Cregg Allison, Nguyen Theo, Holm Tara, Flanagan Siobhan
Final Pr. ID: Poster #: CR-059
Portal hypertension in pediatric patients is rare, most commonly caused by extrahepatic portal vein (PV) occlusion. Complications include gastrointestinal bleeding. If obstruction recanalization or surgical shunt is not feasible, a transjugular intrahepatic portosystemic shunt (TIPS) can be placed. Risks of TIPS include encephalopathy, shunt stenosis, or thrombosis. Tipsitis is rare, occurring in less than 1% of TIPS patients, but is serious, with a mortality of 32%. Early diagnosis and treatment are key to preventing the need for liver transplantation, and imaging plays a key role in early detection. We present a case of tipsitis identified with FDG-PET/CT imaging.
A 16 year-old-male with prematurity, umbilical vein catheter, and heterozygous prothrombin mutation presented with hematemesis. Imaging identified chronic PV thrombosis. Due to the occlusion involving both the right and left PV, TIPS was placed. 5.5 months post-TIPS, he presented with fever and body aches. Investigations revealed Methicillin-Sensitive Staphylococcus aureus (MSSA) bacteremia and thrombosed TIPS. He completed a 6-week course of IV antibiotics, and the TIPS was revised.
Two weeks later, he was readmitted with recurrent MSSA bacteremia. FDG-PET/CT scan was performed, showing increased TIPS uptake, consistent with tipsitis. He completed an additional 8-week IV antibiotic course. Repeat FDG-PET/CT showed decreased but persistent TIPS uptake. IV antibiotics were extended, and he was placed on suppressive oral antibiotics with a plan for FDG-PET/CT in 3 months.
Tipsitis is rare, and early infection (<120 days) is associated with gram-positive bacteria caused by seeding during placement. In this case, later infection was suspected to be caused by Staph aureus superinfection during influenza. Low-grade symptoms include malaise, and high-grade symptoms include fever and rigors. Suspicious CT findings include peri-graft gas or fluid. Radiolabeled leukocyte uptake is specific to infection, but spatial resolution is limited. FDG-PET/CT with focal TIPS metabolic activity (SUV > 8.0) correlates with infection source (sensitivity 91-98%, specificity 64–91%).
Antibiotic therapy is successful in 53% of cases, and FDG-PET/CT can determine the degree of treatment success. Residual hypermetabolic activity signifies partial response. Aggressive antibiotics are recommended to prevent resistance and the need for liver transplant. FDG-PET/CT plays a vital role in diagnosis and management of tipsitis.
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Authors: Cregg Allison , Nguyen Theo , Holm Tara , Flanagan Siobhan
Keywords: Portal Vein Thrombosis, FDG PET, Interventional Radiology