Sung Andrew,  Weiss Brian,  Trout Andrew

Final Pr. ID: Paper #: 147

Despite significant advances in delivering dose-intensive and myeloablative therapy with hematopoietic stem cell support, the survival for patients presenting with metastatic neuroblastoma remains poor, with a 3 year event free survival (EFS) of about 60%. Modern treatment protocols are based on risk stratification which incorporates age of diagnosis, tumor stage, tumor histology, and molecular and cytogenetics including MYCN amplification. ¹⁸F-FDG PET/CT can play a role in disease staging and follow up. The purpose of this study was to report FDG PET findings in a cohort of children with neuroblastoma and assess for predictive associations with MYCN amplification status. Read More

Authors:  Sung Andrew,  Weiss Brian,  Trout Andrew

Keywords:  Neuroblastoma ,  PET ,  Genetics

Nyalakonda Ramyashree,  Muehe Anne,  Iles Benjamin,  Theruvath Ashok,  Siedek Florian,  Agarwal Vibhu,  Hawk Kristina,  Jeng Michael,  Daldrup-link Heike

Final Pr. ID: Paper #: 148

To compare the detection of lesions between DW-MRI and ¹⁸F-FDG PET/MR for staging and restaging of Langerhans Cell Histiocytosis (LCH), using all clinical outcomes and imaging data as the reference standard. Also, this study will compare the differences between LCH chemotherapy responders and non-responders. Read More

Authors:  Nyalakonda Ramyashree,  Muehe Anne,  Iles Benjamin,  Theruvath Ashok,  Siedek Florian,  Agarwal Vibhu,  Hawk Kristina,  Jeng Michael,  Daldrup-link Heike

Keywords:  Langerhans Cell Histiocytosis ,  Diffusion Weighted Imaging ,  18F-FDG PET/MR

Pace Erika,  Clarke Enrico,  Mandeville Henry,  De Souza Nandita

Final Pr. ID: Paper #: 149

To measure and compare early (within 3 months) and late (beyond 3 months) changes in ADC of the clival marrow post-photon and proton therapy. Read More

Authors:  Pace Erika,  Clarke Enrico,  Mandeville Henry,  De Souza Nandita

Keywords:  bone marrow ,  radiotherapy ,  proton beam therapy

Pace Erika,  Vaidya Sucheta,  De Souza Nandita

Final Pr. ID: Paper #: 150

To measure early (within 3 months) and late (beyond 3 months) changes in ADC of the lumbosacral vertebral marrow following chemotherapy in children with abdomino-pelvic neoplasms and interpret them in the context of ADC measurement reproducibility. Read More

Authors:  Pace Erika,  Vaidya Sucheta,  De Souza Nandita

Keywords:  bone marrow ,  chemotherapy ,  abdomino-pelvic neoplasm

Pace Erika,  De Souza Nandita

Final Pr. ID: Paper #: 151

To establish the reproducibility of the apparent diffusion coefficient (ADC) measurement in the bone marrow of the clivus and lumbosacral spine. Read More

Authors:  Pace Erika,  De Souza Nandita

Keywords:  bone marrow ,  reproducibility ,  apparent diffusion coefficient

Marie Eman,  Oudjhane Kamaldine

Final Pr. ID: Paper #: 152

Neuroblastoma (NBL) is the most common extracranial solid malignancy of childhood. Biological features are known to affect disease severity. Status of amplification of the MYCN proto-oncogene is among several factors that affect the prognosis. CT texture analysis of tumor provides a step from qualitative to quantitative assessment, with the added bonus of use of routinely acquired images without the need for further tests. The aim of the study is to ascertain the ability to differentiate between MYCN-amplified and non MYCN-amplified neuroblastoma on pre-treatment CT images. The hypothesis is that lesion microenvironment and heterogeneity may differ significantly between MYCN-amplified and non MYCN-amplified tumor. Such differences may be exhibited in first-order texture analysis techniques that could detect more subtle differences in tumor heterogeneity by quantifying both pixel attenuation. This retrospective study objective is to explore the correlation between the first –order CT texture analysis (CTTA) and MYCN amplification status of neuroblastoma. Read More

Authors:  Marie Eman,  Oudjhane Kamaldine

Keywords:  Neuroblastoma. ,  CT texture. ,  Radiomics

Devkota Laxman,  Bhavane Rohan,  Badachhape Andrew,  Veeramachaneni Ratna,  Stupin Igor,  Bhandari Prajwal,  Ghaghada Ketan,  Sikora Andrew,  Annapragada Ananth

Final Pr. ID: Paper #: 153

The incidence of head and neck malignancies among children has increased substantially in the last five decades. The immunosuppressive tumor micro-environment (TME) represents a major roadblock in the treatment of head and neck tumors. We have demonstrated previously that an elevated level of myeloid derived suppressor cells (MDSC) in the tumor correlates directly with a poor prognosis, and that MDSC levels can be reduced using inhibitors of inducible nitric oxide synthase (iNOS). In this pre-clinical study, we utilized non-contrast magnetic resonance imaging (MRI) and nanoparticle contrast-enhanced computed tomography (CECT) to monitor tumor responses to TME-directed combinatorial therapies that included iNOS inhibition, immunomodulation, checkpoint inhibition, and radiation. Read More

Authors:  Devkota Laxman,  Bhavane Rohan,  Badachhape Andrew,  Veeramachaneni Ratna,  Stupin Igor,  Bhandari Prajwal,  Ghaghada Ketan,  Sikora Andrew,  Annapragada Ananth

Keywords:  Immunotherapy ,  Tumor ,  Imaging

Kiru Louise,  Wu Wei,  Nejadnik Hossein,  Liu Anna,  Majzner Robbie,  Sulchek Todd,  Daldrup-link Heike

Final Pr. ID: Paper #: 154

Metastasized osteosarcoma has a poor prognosis with a two-year event free survival rate of 15-20%, highlighting the need for the advancement of efficacious therapeutics. Chimeric antigen receptor (CAR) T-cell therapy is emerging as a potent strategy for eliminating tumors by harnessing the immune system. Despite this, trials encounter challenges due to varied responses and failing therapy in patients. Development of translatable cell imaging methods would provide invaluable information regarding the biological fate of T-cells. This work aims to evaluate a new approach for CAR T-cell labeling with ferumoxytol, which enables non-invasive cell tracking with magnetic resonance imaging (MRI) and a new imaging technique, magnetic particle imaging (MPI). Read More

Authors:  Kiru Louise,  Wu Wei,  Nejadnik Hossein,  Liu Anna,  Majzner Robbie,  Sulchek Todd,  Daldrup-link Heike

Keywords:  Osteosarcoma ,  Chimeric antigen receptor T cells ,  Cell tracking

Badachhape Andrew,  Tao Ling,  Joshi Sanshuv,  Devkota Laxman,  Stupin Igor,  Sarkar Poonam,  Annapragada Ananth,  Barbieri Eveline,  Ghaghada Ketan

Final Pr. ID: Paper #: 155

Neuroblastoma (NB) is the most common non-cranial solid tumor in childhood. The MYCN oncogene plays a crucial role in tumorigenesis and angiogenesis in NB and is a strong indicator of poor prognosis. The tyrosine hydroxylase (TH)-MYCN transgenic mouse model of NB is extensively utilized; however, little is known about disease progression in this model. In this work, we use multi-modal imaging to study tumor progression and vascular architecture in TH-MYCN transgenic, allograft, and syngeneic mouse models of NB. Read More

Authors:  Badachhape Andrew,  Tao Ling,  Joshi Sanshuv,  Devkota Laxman,  Stupin Igor,  Sarkar Poonam,  Annapragada Ananth,  Barbieri Eveline,  Ghaghada Ketan

Keywords:  Neuroblastoma ,  Magnetic Resonance Imaging ,  Tumor

Holroyd Alexandria,  Bai Harrison,  Liu Shixin,  Xiao Yanhe,  Liu Yalin,  Wu Jing,  States Lisa

Final Pr. ID: Paper #: 156

Neuroblastoma is a clinically heterogeneous pediatric malignancy, varying in location, histopathologic appearance, and biologic characteristics. Genetics plays an important role in the prognosis. Amplification of the MYC family member, MYCN, is found in 25% of cases and correlates with high-risk disease and poor prognosis. However, genetic information can only be obtained via surgery or biopsy with concurrent morbidity and sampling variability associated with biopsy. The ability to detect MYCN amplification from routine pre-operative imaging can stratify neuroblastoma risk groups and affect clinical decision making. The purpose of this study was to predict the patient's MYCN status based on radiomics analysis of the magnetic resonance imaging (MRI) characteristics in patients with neuroblastoma. Read More

Authors:  Holroyd Alexandria,  Bai Harrison,  Liu Shixin,  Xiao Yanhe,  Liu Yalin,  Wu Jing,  States Lisa

Keywords:  Machine learning ,  Radiomics ,  Neuroblastoma

Holroyd Alexandria,  Khrichenko Dmitry,  States Lisa

Final Pr. ID: Paper #: 157

Radiogenomics refers to the correlation of imaging and genomic data of tumors in cancer patients. This study attempts to make correlations between biomarkers in NGS Comprehensive Solid Tumor Panel reports and MRI imaging findings in neuroblastoma patients. Read More

Authors:  Holroyd Alexandria,  Khrichenko Dmitry,  States Lisa

Keywords:  Neuroblastoma ,  Radiogenomics

Dennison Chelsea,  Cummiskey Amy,  Baumgartner James,  Williams Jennifer

Final Pr. ID: Paper #: 158

Single stage corpus callosotomy is a surgery utilized in patients with intractable epilepsy that prevents the spread of seizure impulses to the contralateral hemisphere. This study aimed to evaluate post corpus callosotomy findings on fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT), specifically a finding noted in which a cerebral hemisphere demonstrated new (compared to baseline PET-CT) hypometabolism without corresponding magnetic resonance imaging (MRI) lesion. Our aim was to determine if this finding had clinical relevance in predicting post procedure seizure rates. Read More

Authors:  Dennison Chelsea,  Cummiskey Amy,  Baumgartner James,  Williams Jennifer

Keywords:  Epilepsy ,  Seizure outcomes